Document Detail


Mesangial cell activation in the collagenofibrotic glomerulonephropathy. Case report and review of the literature.
MedLine Citation:
PMID:  9737797     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Collagenofibrotic glomerulonephropathy is a new disease entity of unknown pathogenesis, which is characterized by the deposition of type III collagen within the mesangial matrix. We have investigated a case in which many mesangial cells in the type III collagen-deposited glomeruli were alpha-smooth muscle actin (ASMA) positive and showed an increase of subplasmalemmal filaments, indicating the activation and myofibroblastic transformation. It is suggested that the activated mesangial cells may synthesize the type III collagen deposited in the subendothelial space and mesangial matrix.
Authors:
K Naruse; H Ito; T Moriki; E Miyazaki; Y Hayashi; H Nakayama; H Kiyoku; M Hiroi; T Kurashige; H Enzan
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  433     ISSN:  0945-6317     ISO Abbreviation:  Virchows Arch.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-09-25     Completed Date:  1998-09-25     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  183-8     Citation Subset:  IM    
Affiliation:
First Department of Pathology, Kochi Medical School, Japan.
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MeSH Terms
Descriptor/Qualifier:
Actins / analysis
Aged
Basement Membrane / pathology
Collagen / metabolism*
Complement C3 / analysis
Female
Fibrosis
Glomerular Mesangium / metabolism,  pathology*
Humans
Immunoglobulin M / analysis
Immunohistochemistry
Kidney Diseases / metabolism,  pathology*
Lymphocytes / pathology
Microscopy, Electron
Chemical
Reg. No./Substance:
0/Actins; 0/Complement C3; 0/Immunoglobulin M; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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