Document Detail

Mesalazine-associated benign intracranial hypertension in a patient with ulcerative colitis.
MedLine Citation:
PMID:  12834704     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To report a case of benign intracranial hypertension related to mesalazine use. DESIGN: Observational case report. METHODS: A 23-year-old-woman with sudden visual loss, headache, and a history of ulcerative colitis treated with mesalazine underwent ophthalmologic examination, echography, magnetic resonance imaging, and lumbar puncture. RESULTS: The examinations disclosed benign intracranial hypertension that resolved when mesalazine was discontinued and recurred when the drug was restarted. CONCLUSIONS: We recommend periodic ocular fundus examination for patients undergoing long-term therapy with mesalazine, especially if decreased vision, headaches, or neck stiffness are present, to avoid potentially severe complications of intracranial hypertension
Nicola Rosa; Arcangelo Giamundo; Attilio Jura; Gennarfrancesco Iaccarino; Antonio Romano
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  136     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-01     Completed Date:  2003-07-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  212-3     Citation Subset:  AIM; IM    
Eye Department, 2nd University of Naples, Naples, Italy.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Colitis, Ulcerative / drug therapy*
Headache / chemically induced
Mesalamine / adverse effects*
Optic Nerve / ultrasonography
Pseudotumor Cerebri / chemically induced*,  ultrasonography
Vision Disorders / chemically induced
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 89-57-6/Mesalamine

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