Document Detail

Mesalamine in the prevention of endoscopic recurrence after intestinal resection for Crohn's disease. Italian Cooperative Study Group.
MedLine Citation:
PMID:  7835575     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Recurrence of lesions of Crohn's disease of the ileum within 1 year after so-called curative resection was well documented by endoscopy in 73%-93% of cases. This study investigated the efficacy of mesalamine in reduction of endoscopic recurrence after surgery. METHODS: In a double-blind, multicenter clinical trial, 87 patients were treated with 3 g/day mesalamine (Pentasa) or with placebo within 1 month after surgery. After 12 months of treatment, severity of endoscopic lesions was recorded with a five-point score; when it was not possible to reach the anastomosis by endoscopy, a barium enema was performed. RESULTS: Seventeen clinical relapses (seven in the mesalamine group) were recorded. After 12 months, the endoscopic lesions were less frequent and less severe in the mesalamine group than were those in the placebo group (chi 2, 13.5; P < 0.008). The overall rate of severe recurrence (score of 3-4 on endoscopy or radiological documentation) was 24% in the mesalamine group and 56% in the placebo group (chi 2, 8.57; P < 0.004; difference 32%; 95% confidence interval, 22-52). The odds ratio for active treatment was 4.1. CONCLUSIONS: This study shows that mesalamine is useful in decreasing the rate and severity of endoscopic recurrences after curative surgery for ileal Crohn's disease.
C Brignola; M Cottone; A Pera; S Ardizzone; M L Scribano; R De Franchis; A D'Arienzo; G D'Albasio; D Pennestri
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Gastroenterology     Volume:  108     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-03-01     Completed Date:  1995-03-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  345-9     Citation Subset:  AIM; IM    
Istituto di Clinica Medica e Gastroenterologia, Università di Bologna, Italy.
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MeSH Terms
Aminosalicylic Acids / therapeutic use*
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Crohn Disease / prevention & control*,  surgery
Double-Blind Method
Middle Aged
Regression Analysis
Treatment Outcome
Reg. No./Substance:
0/Aminosalicylic Acids; 0/Anti-Inflammatory Agents, Non-Steroidal; 89-57-6/Mesalamine

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