| Merthiolate treatment of pathogenic fungi. | |
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MedLine Citation:
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PMID: 389944 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The action of Merthiolate on the pathogenic yeasts Blastomyces, dermatitidis, Histoplasma capsulatum, and Sporothrix schenckii was compared to the effect of treatment with formaldehyde. Concentrations of 1:10,000 and 1:5,000 Merthiolate for three exposure times (24, 48, and 72 h) at 4 and 25 degrees C were tested on three media (brain heart infusion with and without blood, and modified Sabouraud agar). The effect of Merthiolate on these three yeasts was primarily fungistatic, with maximum effect using 1:5,000 Merthiolate at 25 degrees C for at least 48 h. Mycelial suspensions of B. dermatitidis, H. capsulatum, S. shenckii, and the yeast phase of Cryptococcus neoformans were susceptible to the 1:5,000 Merthiolate concentration after 24 h of treatment. The antifungal effect of Methiolate varies with species and growth phase of the fungus. Concentration, time of exposure, and temperature of incubation are important variables. |
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Authors:
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F J Deighton; N K Hall; H W Larsh |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of clinical microbiology Volume: 10 ISSN: 0095-1137 ISO Abbreviation: J. Clin. Microbiol. Publication Date: 1979 Aug |
Date Detail:
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Created Date: 1980-02-28 Completed Date: 1980-02-28 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505564 Medline TA: J Clin Microbiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 144-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blastomyces
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drug effects*,
growth & development Cryptococcus / drug effects* Cryptococcus neoformans / drug effects*, growth & development Ethylmercury Compounds / pharmacology* Histoplasma / drug effects*, growth & development Sporothrix / drug effects*, growth & development Temperature Thimerosal / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Ethylmercury Compounds; 54-64-8/Thimerosal |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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