Document Detail


Merkel cells in the oral mucosa.
MedLine Citation:
PMID:  16959700     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ninety-eight consecutive surgical biopsies of oral mucosa from 96 patients were evaluated immunohistochemically with an anti-cytokeratin 20 (CK 20) anti-body to evidence Merkel cells (MC). Fifteen cases, showing the highest number of MC, were additionally studied with chromogranin A, S-100 protein, neuro filaments, epithelial membrane antigen, and double immunostaining for CK 20 and Ki67 antibodies to evaluate MC proliferation. Electron microscopy was performed in 2 cases. MC were observed in 58 cases. The highest number of MC was found in the gingival, buccal, and palate mucosa, especially in chronically damaged oral mucosa (lichen and chronic aspecific inflammation) as well as in the mucosa overlying tumors rather than in normal or acute inflammation. MC were not observed in dysplastic or neoplastic epithelium. MC showed evidence of proliferation, as demonstrated by Ki67 positivity, in 3 cases. In conclusion, MC appear to play a role in the reparative processes of oral mucosa.
Authors:
Alberto Righi; Christine M Betts; Claudio Marchetti; Gianluca Marucci; Lucio Montebugnoli; Carlo Prati; Leonardo H U Eusebi; Luciana Muzzi; Teresa Ragazzini; Maria P Foschini
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of surgical pathology     Volume:  14     ISSN:  1066-8969     ISO Abbreviation:  Int. J. Surg. Pathol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-09-08     Completed Date:  2006-10-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9314927     Medline TA:  Int J Surg Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  206-11     Citation Subset:  IM    
Affiliation:
Section of Anatomic Pathology, Bellaria Hospital, University of Bologna, Bologna, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Biological Markers / analysis
Biopsy
Cell Count
Cell Proliferation
Child
Child, Preschool
Humans
Immunohistochemistry
Keratin-20
Keratins / analysis
Merkel Cells / chemistry,  pathology*,  ultrastructure
Middle Aged
Mouth Mucosa / chemistry,  pathology*,  ultrastructure
Chemical
Reg. No./Substance:
0/Biological Markers; 0/KRT20 protein, human; 0/Keratin-20; 68238-35-7/Keratins

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