Document Detail

Merkel cell polyomavirus is present in common warts and carcinoma in situ of the skin.
MedLine Citation:
PMID:  20655089     Owner:  NLM     Status:  MEDLINE    
Polyomaviruses have been linked to diseases of immunosuppressed patients. We sought to determine the prevalence of Merkel cell polyomavirus in benign epithelial skin neoplasms and nonmelanoma skin cancer of immunosuppressed renal transplant recipients and long-term dialysis patients. Merkel cell polyomavirus DNA was detected by polymerase chain reaction (PCR) in 2 (10%) of 20 patients, in carcinomas in situ (Bowen's disease). In one of our patients with Merkel cell polyomavirus-positive carcinoma in situ, 9 (39.1%) of 23 skin lesions at various anatomical locations tested positive for Merkel cell polyomavirus sequences by PCR, including all of his common warts (4/4), half of his carcinoma in situ lesions (3/6), and 2 of his 3 seborrheic keratoses. In a second cohort of immunosuppressed renal transplant recipients, Merkel cell polyomavirus DNA was found in 1 (6.3%) of 16 common warts and in 2 (9.5%) of 21 carcinomas in situ. In immunocompetent individuals, Merkel cell polyomavirus DNA was found in 2 (6.7%) of 30 common warts and in 2 (8.3%) of 24 carcinomas in situ. DNA of other human polyomaviruses was not detected in any of the investigated skin neoplasms. We conclude that common warts and carcinomas in situ can be positive for Merkel cell polyomavirus in immunosuppressed as well as immunocompetent individuals. Remarkably, some of the Merkel cell polyomavirus-positive common warts did not contain human papillomavirus. Furthermore, Merkel cell polyomavirus can be found in various skin neoplasms of the same individual.
Kirsten D Mertz; Madeleine Pfaltz; Tobias Junt; Mirka Schmid; Maria Teresa Fernandez Figueras; Katrin Pfaltz; André Barghorn; Werner Kempf
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Publication Detail:
Type:  Journal Article     Date:  2010-07-22
Journal Detail:
Title:  Human pathology     Volume:  41     ISSN:  1532-8392     ISO Abbreviation:  Hum. Pathol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2010-10-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1369-79     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Kempf & Pfaltz Histological Diagnostics, Research Unit, Zurich, Switzerland.
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MeSH Terms
Aged, 80 and over
Bowen's Disease / immunology,  pathology,  virology*
Carcinoma in Situ / immunology,  pathology,  virology*
DNA, Viral / analysis
Immunocompromised Host
Kidney Transplantation
Merkel Cells / virology*
Middle Aged
Polymerase Chain Reaction
Polyomavirus / genetics,  isolation & purification*
Renal Dialysis
Skin / pathology,  virology
Skin Neoplasms / immunology,  pathology,  virology*
Warts / immunology,  pathology,  virology*
Reg. No./Substance:
0/DNA, Viral

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