| Merkel cell carcinoma with sarcomatous differentiation: is it a poor prognostic factor? | |
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MedLine Citation:
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PMID: 23278615 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background Poor prognostic factors in Merkel cell carcinoma include male sex, advanced stage at diagnosis, large tumor size (>5 mm), diffuse growth pattern, heavy lymphocytic infiltrate, and high mitotic rate. To date only six cases of Merkel cell carcinoma with sarcomatous or pseudosarcomatous differentiation and poor prognosis have been documented. Methods We present a new case of Merkel cell carcinoma with sarcomatous differentiation. Results The immunohistochemical staining patterns reflected the morphologic differentiation of the epithelial and sarcomatous pattern. After two months of follow-up, there were no signs of local recurrence or metastases. Conclusion In all cases of merkelomas with sarcomatous differentiation described to date, lymph node metastases have been found, except in the presented case. However, larger series of cases will be required to determine if sarcomatous differentiation represents another negative prognostic factor. |
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Authors:
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Elisabeth Gomez-Moyano; Angel Vera-Casaño; Andrés Sanz-Trelles; Leandro Martinez |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of dermatology Volume: 52 ISSN: 1365-4632 ISO Abbreviation: Int. J. Dermatol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0243704 Medline TA: Int J Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 93-5 Citation Subset: IM |
Copyright Information:
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© 2013 The International Society of Dermatology. |
Affiliation:
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Departments of Dermatology Pathology, Hospital Carlos Haya, Málaga, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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