| Merkel cell carcinoma: Is this a true carcinoma? | |
MedLine Citation:
|
PMID: 25040178 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Recent years have brought an enhanced understanding of Merkel cell carcinoma (MCC) biology, especially with regards to the Merkel cell polyoma virus as a causative agent. Differences between Merkel cell polyomavirus-positive and -negative MCC in morphology,, gene expression, miRNA profiles and prognosis have been reported. Origin of MCC is controversial. Presence of neurosecretory granules has suggested that these carcinomas originate from one of the neurocrest derivatives, most probably Merkel cells; the name Merkel cell carcinoma is now widely accepted. Expression of PGP 9.5, chromogranin A and several neuropeptides, initially regarded as specific markers for neural and neuroendocrine cells, has recently been shown in a subset of lymphomas. MCC commonly express terminal deoxynucleotidyl transferase and PAX5. Their co-expression under physiologic circumstances is restricted to pro/pre-B cells and pre-B cells. These findings lead to the hypothesis by zur Hausen et al. that MCC originates from early B-cells. This review was intended to critically appraise zur Hausen's hypothesis and discuss the possibility that MCC is a heterogenous entity with distinct subtypes. This article is protected by copyright. All rights reserved. |
Authors:
|
Marek Jankowski; Piotr Kopinski; Robert Schwartz; Rafal Czajkowski |
Related Documents
:
|
23772398 - Calretinin mediates apoptosis in small cell lung cancer cells expressing tetraspanin cd9. 23049868 - Efficient generation of virus-free ips cells using liposomal magnetofection. 22986528 - Depleting ifit2 mediates atypical pkc signaling to enhance the migration and metastatic... 23851218 - 7α-hydroxylation of dehydroepiandrosterone does not interfere with the activation of gl... 23726908 - Influence of focal adhesion kinase on the mechanical behavior of cell populations. 22077798 - F-actin is a substrate for protealysin, a metalloprotease of invasive serratia proteama... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2014-7-9 |
Journal Detail:
|
Title: Experimental dermatology Volume: - ISSN: 1600-0625 ISO Abbreviation: Exp. Dermatol. Publication Date: 2014 Jul |
Date Detail:
|
Created Date: 2014-7-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9301549 Medline TA: Exp Dermatol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
This article is protected by copyright. All rights reserved. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reply to Lutrin: Decision-making in colorectal surgery.
Next Document: Relationship between genuine and pseudohalitosis and social anxiety disorder.