Document Detail

Merkel cell carcinoma of the head and neck associated with Bowen's disease.
MedLine Citation:
PMID:  1722678     Owner:  NLM     Status:  MEDLINE    
The Merkel cell carcinoma occurs primarily in the skin of the head and neck, and develops in the dermis with a trabecular growth pattern. Immunohistochemistry reveals positive staining for neuron-specific enolase, neurofilaments, cytokeratin and chromogranin A. Electron microscopically, the tumor cells contain dense-core granules, spinous cytoplasmic processes, desmosomes, zonulae adherentes and paranuclear filament aggregates besides frequent mitoses, focal necroses and lymphocyte and plasma cell infiltrates. The Merkel cell carcinoma is often co-existent with other malignancies such as squamous cell carcinoma or, as in the present study, with Bowen's disease. The definite diagnosis of the Merkel cell carcinoma can be effected only by electron microscopic examination of the tumor.
P Schenk; K Konrad
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery     Volume:  248     ISSN:  0937-4477     ISO Abbreviation:  Eur Arch Otorhinolaryngol     Publication Date:  1991  
Date Detail:
Created Date:  1992-02-26     Completed Date:  1992-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9002937     Medline TA:  Eur Arch Otorhinolaryngol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  436-41     Citation Subset:  IM    
Department of Otorhinolaryngology II, University of Vienna Medical School, Austria.
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MeSH Terms
Bowen's Disease* / metabolism,  ultrastructure
Carcinoma, Merkel Cell* / chemistry,  ultrastructure
Chromogranin A
Chromogranins / analysis
Immunoenzyme Techniques
Keratins / analysis
Neoplasms, Multiple Primary* / chemistry,  ultrastructure
Phosphopyruvate Hydratase / analysis
Skin Neoplasms* / chemistry,  ultrastructure
Reg. No./Substance:
0/Chromogranin A; 0/Chromogranins; 68238-35-7/Keratins; EC Hydratase

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