Document Detail

Merkel cell carcinoma.
MedLine Citation:
PMID:  21422993     Owner:  NLM     Status:  MEDLINE    
Merkel cell carcinoma (MCC) is a rare, clinically aggressive cutaneous neuroendocrine neoplasm with a high mortality rate. Though the etiology is not precisely known, Merkel cell polyomavirus DNA has been found recently in a large percentage of MCC tumors. Other suggested risk factors include sun exposure, immunosuppression, and a history of prior malignancy. Work up of patients with MCC most notably includes nodal staging via clinical examination or sentinel lymph node biopsy. The prognosis for most patients with MCC is poor, and the rarity of MCC precludes the prospective, randomized clinical trials necessary to elucidate optimum treatment protocols. Most published data support the use of a multimodality approach centered around surgical excision with negative margins, sentinel lymph node biopsy to establish the presence or absence of nodal metastases, adjuvant radiothearpy to decrease the risk of recurrence, and systemic chemotherapy in the case of widespread disease.
Emma Ramahi; Jehee Choi; Clifton D Fuller; Tony Y Eng
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  American journal of clinical oncology     Volume:  36     ISSN:  1537-453X     ISO Abbreviation:  Am. J. Clin. Oncol.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-17     Completed Date:  2013-07-11     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  8207754     Medline TA:  Am J Clin Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  299-309     Citation Subset:  IM    
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MeSH Terms
Carcinoma, Merkel Cell / diagnosis,  therapy*
Combined Modality Therapy
Skin Neoplasms / diagnosis,  therapy*
Grant Support
5T32EB000817-04/EB/NIBIB NIH HHS; L30 CA136381/CA/NCI NIH HHS; L30 CA136381/CA/NCI NIH HHS; L30 CA136381-02/CA/NCI NIH HHS; T32 EB000817-05/EB/NIBIB NIH HHS

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