| Merits of Non-Invasive Rat Models of Left Ventricular Heart Failure. | |
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MedLine Citation:
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PMID: 21279739 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Heart failure (HF) is characterized as a limitation to cardiac output that prevents the heart from supplying tissues with adequate oxygen and predisposes individuals to pulmonary edema. Impaired cardiac function is secondary to either decreased contractility reducing ejection (systolic failure), diminished ventricular compliance preventing filling (diastolic failure), or both. To study HF etiology, many different techniques have been developed to elicit this condition in experimental animals, with varying degrees of success. Among rats, surgically induced HF models are the most prevalent, but they bear several shortcomings, including high mortality rates and limited recapitulation of the pathophysiology, etiology, and progression of human HF. Alternatively, a number of non-invasive HF induction methods avoid many of these pitfalls, and their merits in technical simplicity, reliability, survivability, and comparability to the pathophysiologic and pathogenic characteristics of HF are reviewed herein. In particular, this review focuses on the primary pathogenic mechanisms common to genetic strains (spontaneously hypertensive and spontaneously hypertensive heart failure), pharmacological models of toxic cardiomyopathy (doxorubicin and isoproterenol), and dietary salt models, all of which have been shown to induce left ventricular HF in the rat. Additional non-invasive techniques that may potentially enable the development of new HF models are also discussed. |
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Authors:
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Alex P Carll; Monte S Willis; Robert M Lust; Daniel L Costa; Aimen K Farraj |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-30 |
Journal Detail:
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Title: Cardiovascular toxicology Volume: - ISSN: 1559-0259 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101135818 Medline TA: Cardiovasc Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, 148 Rosenau Hall, CB# 7431, Chapel Hill, NC, 27599, USA, carll@unc.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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