Document Detail


Merging mythology and morphology: the multifaceted lifestyle of Proteus mirabilis.
MedLine Citation:
PMID:  23042564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Proteus mirabilis, named for the Greek god who changed shape to avoid capture, has fascinated microbiologists for more than a century with its unique swarming differentiation, Dienes line formation and potent urease activity. Transcriptome profiling during both host infection and swarming motility, coupled with the availability of the complete genome sequence for P. mirabilis, has revealed the occurrence of interbacterial competition and killing through a type VI secretion system, and the reciprocal regulation of adhesion and motility, as well as the intimate connections between metabolism, swarming and virulence. This Review addresses some of the unique and recently described aspects of P. mirabilis biology and pathogenesis, and emphasizes the potential role of this bacterium in single-species and polymicrobial urinary tract infections.
Authors:
Chelsie E Armbruster; Harry L T Mobley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-10-08
Journal Detail:
Title:  Nature reviews. Microbiology     Volume:  10     ISSN:  1740-1534     ISO Abbreviation:  Nat. Rev. Microbiol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-16     Completed Date:  2013-01-08     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101190261     Medline TA:  Nat Rev Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  743-54     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Immunology, University of Michigan Medical School, 1150 West Medical Center Drive, 5641 Medical Science Building II, Ann Arbor, Michigan 48109, USA.
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MeSH Terms
Descriptor/Qualifier:
Bacterial Adhesion
Bacterial Proteins / metabolism
Bacterial Secretion Systems / physiology
Catheter-Related Infections / microbiology
Gene Expression Regulation, Bacterial
Gene Transfer, Horizontal
Humans
Immune Evasion
Proteus Infections / microbiology*
Proteus mirabilis / genetics,  pathogenicity*,  physiology*
Urinary Tract Infections / microbiology*
Virulence Factors / metabolism
Grant Support
ID/Acronym/Agency:
AI43363/AI/NIAID NIH HHS; AI59722/AI/NIAID NIH HHS; DK94777/DK/NIDDK NIH HHS; F32 AI102552/AI/NIAID NIH HHS; F32AI102552/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/Virulence Factors
Comments/Corrections

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