Document Detail


Merging models and biomonitoring data to characterize sources and pathways of human exposure to organophosphorus pesticides in the Salinas Valley of California.
MedLine Citation:
PMID:  17539531     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We characterize cumulative intakes of organophosphorus (OP) pesticides in an agricultural region of California by drawing on human biomonitoring data, California pesticide use reporting (PUR) data, and limited environmental samples together with outputs from the CalTOX multimedia, multipathway, source-to-dose model. The study population is the CHAMACOS cohort of almost 600 pregnant Latina women in the Salinas Valley region. We use model estimates of OP intake and urinary dialkylphosphate (DAP) metabolite excretion to develop premises about relative contributions from different exposure sources and pathways. We evaluate these premises by comparing the magnitude and variation of DAPs in the CHAMACOS cohort with those of the whole U.S. population using data from the National Health and Nutrition Examination Survey (NHANES). This comparison supports the premise that diet is the common and dominant exposure pathway in both populations. Biomarker comparisons and model results support the observation that, relative to NHANES, the CHAMACOS population has a statistically significant (p < 0.001) added intake of OP pesticides with low inter-individual variability. We attribute the magnitude and small variance of this intake to residential nondietary exposures from local agricultural OP uses. These results show that mass-balance models can estimate exposures for OP pesticides within the range measured by biological monitoring.
Authors:
Thomas E McKone; Rosemary Castorina; Martha E Harnly; Yu Kuwabara; Brenda Eskenazi; Asa Bradman
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Environmental science & technology     Volume:  41     ISSN:  0013-936X     ISO Abbreviation:  Environ. Sci. Technol.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-06-01     Completed Date:  2007-06-29     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3233-40     Citation Subset:  IM    
Affiliation:
Lawrence Berkeley National Laboratory, Berkeley, California, Center for Children's Environmental Health Research, School of Public Health, University of California, Berkeley, California, USA. temckone@LBL.gov
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MeSH Terms
Descriptor/Qualifier:
Adult
Air Pollution, Indoor / analysis
California
Diet
Dust / analysis
Environmental Exposure / analysis*
Environmental Monitoring
Environmental Pollutants / analysis*,  urine
Female
Food Contamination
Humans
Models, Theoretical*
Organophosphorus Compounds / analysis*,  urine
Pesticide Residues / analysis,  urine
Pesticides / analysis*,  urine
Pregnancy
Grant Support
ID/Acronym/Agency:
P01 ES009605/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Dust; 0/Environmental Pollutants; 0/Organophosphorus Compounds; 0/Pesticide Residues; 0/Pesticides
Comments/Corrections
Comment In:
Environ Sci Technol. 2007 May 1;41(9):3036-7   [PMID:  17539500 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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