Document Detail


Mercury vapour (Hg(0)): Continuing toxicological uncertainties, and establishing a Canadian reference exposure level.
MedLine Citation:
PMID:  18992295     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are four published reference exposure levels (RELs) for Hg(0), ranging from 0.09microg/m(3) to 1microg/m(3). All RELs were derived from the same toxicological database, predominantly of male chloralkali workers. Some key factors are apparent which make the use of that database questionable for REL derivation. Occupational studies of chloralkali workers are not an appropriate basis for a REL for Hg(0). Concomitant exposure to chlorine gas (Cl(2)) diminishes uptake and effects of Hg(0) exposure. There are gender differences in Hg(0) uptake, distribution and excretion, with females at potentially greater risk from Hg(0) exposure than males. Studies of chloralkali workers focused almost exclusively on adult males. Recent investigations of dental professionals (dentists, technicians, assistants) have failed to define a threshold in the dose-response relationship linking Hg(0) with neurobehavioural outcomes, an observation generally ignored in Hg(0) REL development. Finally, there is a growing database on genetic predisposition to health effects associated with Hg(0) exposure. Based on these considerations, we propose a different key study for REL derivation, one that involved male and female dental professionals without concomitant Cl(2) exposure. Adjusting the LOEAL to continuous exposure and applying appropriate UF values, we propose a Canadian REL for Hg(0) of 0.06microg/m(3).
Authors:
G Mark Richardson; Ronald W Brecher; Hugh Scobie; Jane Hamblen; John Samuelian; Cindy Smith
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-01
Journal Detail:
Title:  Regulatory toxicology and pharmacology : RTP     Volume:  53     ISSN:  1096-0295     ISO Abbreviation:  Regul. Toxicol. Pharmacol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-02     Completed Date:  2009-03-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214983     Medline TA:  Regul Toxicol Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  32-8     Citation Subset:  IM    
Affiliation:
Contaminated Sites Division, Health Canada, Ottawa, Ont., Canada K1A 0K9.
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MeSH Terms
Descriptor/Qualifier:
Air Pollutants, Occupational / analysis*,  pharmacokinetics,  toxicity
Animals
Canada
Chlorine / toxicity
Databases, Factual
Dose-Response Relationship, Drug
Drug Interactions
Female
Genetic Predisposition to Disease / epidemiology
Humans
Inhalation Exposure / adverse effects*
Male
Mercury / analysis*,  pharmacokinetics,  toxicity
No-Observed-Adverse-Effect Level
Occupational Exposure*
Reference Values
Sex Factors
Chemical
Reg. No./Substance:
0/Air Pollutants, Occupational; 7439-97-6/Mercury; 7782-50-5/Chlorine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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