Document Detail

Mercury toxicity presenting as chronic fatigue, memory impairment and depression: diagnosis, treatment, susceptibility, and outcomes in a New Zealand general practice setting (1994-2006).
MedLine Citation:
PMID:  16891999     Owner:  NLM     Status:  MEDLINE    
In a group of 465 patients diagnosed as having chronic mercury toxicity (CMT), 32.3% had severe fatigue, 88.8% had memory loss, and 27.5% had depression. A significant correlation was found between CMT and the Apo-lipoprotein E4 genotype (p=0.001). An investigation into an additional 864 consecutively seen general practice patients, resulted in 30.3% having evidence consistent with CMT, and once again a significant correlation was found with the APO-E4 genotype (p=0.001). Removal of amalgam mercury fillings when combined with appropriate treatment resulted in a significant symptom reduction (p<0.001) to levels reported by healthy subjects.
Damian P Wojcik; Michael E Godfrey; Derek Christie; Boyd E Haley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuro endocrinology letters     Volume:  27     ISSN:  0172-780X     ISO Abbreviation:  Neuro Endocrinol. Lett.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008373     Medline TA:  Neuro Endocrinol Lett     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  415-23     Citation Subset:  IM    
Northland Environmental Health Clinic, 2 Dip Rd, Kamo, Whangarei, Northland, New Zealand.
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MeSH Terms
Apolipoprotein E2 / genetics,  metabolism
Chronic Disease
Dental Amalgam / adverse effects
Dental Restoration, Permanent
Depression / chemically induced*,  diagnosis,  genetics
Fatigue / chemically induced*,  diagnosis,  genetics
Genetic Predisposition to Disease
Memory Disorders / chemically induced*,  diagnosis,  genetics
Mercury / adverse effects,  pharmacokinetics
Mercury Poisoning / diagnosis*,  genetics,  therapy*
Middle Aged
New Zealand
Reg. No./Substance:
0/Apolipoprotein E2; 7439-97-6/Mercury; 8049-85-2/Dental Amalgam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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