Document Detail


Mercury induced time-dependent alterations in lipid profiles and lipid peroxidation in different body organs of cat-fish Heteropneustes fossilis.
MedLine Citation:
PMID:  2708789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of mercuric chloride (HgCl2) on lipid profiles and lipid peroxidation in different body organs of fresh water cat-fish Heteropneustes fossilis were studied. The daily exposure of HgCl2 0.2 mg/L for 10, 20 and 30 days depleted the total lipids in brain. But the content of phospholipids enhanced significantly at 30 days. Significant diminution in C/P ratio was discernible with 30 days of exposure following mercury toxicosis. Liver exhibited elevated levels of total lipids, phospholipids, cholesterol and C/P ratio. Interestingly kidney showed marked decrease in the concentration of total lipids, cholesterol and C/P ratio at higher exposure. However, the phospholipid values increased during the longer exposure. The content of total lipids and phospholipids was high in muscle but the level of cholesterol and C/P ratio were depleted. Significant increment in lipid peroxidation was discernible in brain, liver and muscle. In kidney the rate of lipid peroxidation was significantly reduced. The results suggest that exposure of HgCl2 enhances the peroxidation of endogenous lipids in brain, liver and muscle. Interestingly the lipid contents are affected differently in different body organs.
Authors:
Y Bano; M Hasan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes     Volume:  24     ISSN:  0360-1234     ISO Abbreviation:  J Environ Sci Health B     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-05-31     Completed Date:  1989-05-31     Revised Date:  2009-07-21    
Medline Journal Info:
Nlm Unique ID:  7607167     Medline TA:  J Environ Sci Health B     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  145-66     Citation Subset:  IM    
Affiliation:
Interdisciplinary Brain Research Centre, Jawaharlal Nehru Medical College, Aligarh Muslim University, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / drug effects
Catfishes / blood*
Dose-Response Relationship, Drug
Kidney / drug effects
Lipid Peroxidation / drug effects*
Lipids / blood*
Liver / drug effects
Mercuric Chloride / toxicity*
Muscles / drug effects
Water Pollutants / toxicity*
Water Pollutants, Chemical / toxicity*
Chemical
Reg. No./Substance:
0/Lipids; 0/Water Pollutants; 0/Water Pollutants, Chemical; 7487-94-7/Mercuric Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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