| Mercury exposure and neurochemical impacts in bald eagles across several Great Lakes states. | |
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MedLine Citation:
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PMID: 21735125 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In this study, we assessed mercury (Hg) exposure in several tissues (brain, liver, and breast and primary feathers) in bald eagles (Haliaeetus leucocephalus) collected from across five Great Lakes states (Iowa, Michigan, Minnesota, Ohio, and Wisconsin) between 2002-2010, and assessed relationships between brain Hg and neurochemical receptors (NMDA and GABA(A)) and enzymes (glutamine synthetase (GS) and glutamic acid decarboxylase (GAD)). Brain total Hg (THg) levels (dry weight basis) averaged 2.80 μg/g (range: 0.2-34.01), and levels were highest in Michigan birds. THg levels in liver (r ( p ) = 0.805) and breast feathers (r ( p ) = 0.611) significantly correlated with those in brain. Brain Hg was not associated with binding to the GABA(A) receptor. Brain THg and inorganic Hg (IHg) were significantly positively correlated with GS activity (THg r ( p ) = 0.190; IHg r ( p ) = 0.188) and negatively correlated with NMDA receptor levels (THg r ( p ) = -0245; IHg r ( p ) = -0.282), and IHg was negatively correlated with GAD activity (r ( s ) = -0.196). We also report upon Hg demethylation and relationships between Hg and Se in brain and liver. These results suggest that bald eagles in the Great Lakes region are exposed to Hg at levels capable of causing subclinical neurological damage, and that when tissue burdens are related to proposed avian thresholds approximately 14-27% of eagles studied here may be at risk. |
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Authors:
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Jennifer Rutkiewicz; Dong-Ha Nam; Thomas Cooley; Kay Neumann; Irene Bueno Padilla; William Route; Sean Strom; Niladri Basu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-7 |
Journal Detail:
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Title: Ecotoxicology (London, England) Volume: - ISSN: 1573-3017 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9885956 Medline TA: Ecotoxicology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Environmental Health Sciences, University of Michigan School of Public Health, 109 S. Observatory St, Ann Arbor, MI, 48109, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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