Document Detail


Mercapturates in the urine of persons exposed to N,N-dimethylformamide.
MedLine Citation:
PMID:  4020116     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
N,N-dimethylformamide, a nucleophilic aprotic dipolar solvent, has multipurpose uses, especially in the manufacture of plastics. Its acute toxicity for mammals is low; it is hepatotoxic. Vapors are absorbed by the lungs, in the liquid form it causes cutaneous maceration and is rapidly absorbed through the skin. In the organism it is primarily metabolized to N-monomethylformamide, to a lesser extent to formamide. Urine of individuals exposed to N,N-dimethylformamide was newly found to have higher levels of thioethers, most likely mercapturates, as yet of unknown chemical structure. The correlation between the urinary concentrations of mercapturates (y) and N-monomethylformamide (x) can be expressed by equation y = 4.93 + 0.58 x, with the coefficient of correlation r = 0.90. Part of N,N-dimethylformamide metabolites is likely to react with biopolymers, part of it is excreted as metabolic end products, i.e. carbon dioxide, water and urea. Breakdown to mercapturates may implicate N,N-dimethylformamide as being a potential carcinogen.
Authors:
Z Bardodĕj; H Malonová; M Mráz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hygiene, epidemiology, microbiology, and immunology     Volume:  29     ISSN:  0022-1732     ISO Abbreviation:  J Hyg Epidemiol Microbiol Immunol     Publication Date:  1985  
Date Detail:
Created Date:  1985-09-16     Completed Date:  1985-09-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985116R     Medline TA:  J Hyg Epidemiol Microbiol Immunol     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylcysteine / metabolism,  urine*
Biotransformation
Dimethylformamide / adverse effects*
Formamides / urine
Humans
Chemical
Reg. No./Substance:
0/Formamides; 123-39-7/methylformamide; 616-91-1/Acetylcysteine; 68-12-2/Dimethylformamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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