| Meptazinol and ethanol: a fatal intoxication. | |
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MedLine Citation:
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PMID: 22290756 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Meptazinol (Meptid(®)) is an analgesic drug that is used to treat mild to moderate pain including postoperative pain, obstetrical pain, and the pain of renal colic. This case reports a death due to the combined effects of meptazinol and alcohol in a man with significant heart disease and alcoholic liver disease. A 57-year-old male was found unresponsive in his bed at home with empty blister packets of meptazinol around him. A general drug screen detected the presence of meptazinol, and caffeine and metabolites, in cardiac blood. Analysis, both quantitative (HPLC-DAD) and qualitative (HPLC-DAD, LC-MS), of meptazinol was carried out. Meptazinol was found at the following concentrations: 15.5 mg/L in unpreserved femoral blood; 18.6 mg/L in preserved (fluoride-oxalate) femoral blood; 52.1 mg/L in unpreserved cardiac blood; 16.8 mg/L in preserved vitreous; 61.7 mg/L in unpreserved urine; and 9.8 g/L in stomach contents. Ethanol, analyzed by headspace GC-FID, was present in preserved (fluoride-oxalate) femoral venous blood, urine, and vitreous at concentrations of 232 mg/100 mL, 297 mg/100 mL, and 192 mg/100 mL, respectively. Death was attributed to meptazinol and ethanol toxicity, with atherosclerotic coronary artery disease as a contributing factor. |
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Authors:
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Peter D Maskell; Giorgia De Paoli; L Nitin Seetohul; Derrick J Pounder |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of analytical toxicology Volume: 36 ISSN: 1945-2403 ISO Abbreviation: J Anal Toxicol Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7705085 Medline TA: J Anal Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 69-73 Citation Subset: IM |
Affiliation:
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Centre for Forensic and Legal Medicine, University of Dundee, Dundee, DD1 4HN Scotland, United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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