Document Detail


Mepolizumab in eosinophilic disorders.
MedLine Citation:
PMID:  21790283     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mepolizumab (Bosatria(®), GlaxoSmithKline) is a biologic agent developed to treat asthma. It represents a humanized monoclonal antibody of IgG1 κ type, which targets human IL-5 and thus prevents its interaction with the α-chain of the IL-5 receptor. To date, it has not been approved for use in any eosinophil-related disorder; however, several studies have suggested some therapeutic benefit across a spectrum of eosinophil-related disorders. This article evaluates the currently available preclinical and clinical studies, and the impact of mepolizumab against a variety of eosinophilic disorders.
Authors:
J Pablo Abonia; Philip E Putnam
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of clinical immunology     Volume:  7     ISSN:  1744-8409     ISO Abbreviation:  Expert Rev Clin Immunol     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-27     Completed Date:  2011-11-15     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  101271248     Medline TA:  Expert Rev Clin Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  411-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Monoclonal / pharmacology,  therapeutic use*
Antibodies, Monoclonal, Humanized
Asthma / drug therapy*,  immunology
Churg-Strauss Syndrome / drug therapy*,  immunology
Clinical Trials as Topic
Drug Evaluation, Preclinical
Eosinophilia
Eosinophils / drug effects*,  immunology
Humans
Hypereosinophilic Syndrome / drug therapy*,  immunology
Interleukin-5 / immunology,  metabolism
Grant Support
ID/Acronym/Agency:
R01 DK076893/DK/NIDDK NIH HHS; R01 DK076893-03S1/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 0/IL5 protein, human; 0/Interleukin-5; 0/mepolizumab
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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