| Mephenytoin hydroxylation in the Cuna Amerindians of Panama. | |
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MedLine Citation:
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PMID: 3370193 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1 Mephenytoin p(4')-hydroxylation, which is deficient in 3-5% of Caucasians, was examined in 96 Cuna Amerindians of Panama. 2 Attempts were made to exclude poor compliance with urine collection and ingestion of the drug dose since the assignment of phenotype was based upon urinary recovery of the metabolite. These involved the measurement of the urinary recovery of sparteine, added to the ingested capsule, and of the renal excretion of creatinine. 3 Of the 90 Cunas deemed to be reasonably complaint, none of them appeared to be deficient in p(4')-hydroxylation of mephenytoin. |
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Authors:
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T Inaba; L F Jorge; T D Arias |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 25 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1988 Jan |
Date Detail:
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Created Date: 1988-07-05 Completed Date: 1988-07-05 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 75-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Faculty of Medicine, University of Toronto, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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European Continental Ancestry Group Humans Hydantoins / metabolism* Hydroxylation Indians, Central American* Mephenytoin / metabolism*, urine Panama Polymorphism, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Hydantoins; 50-12-4/Mephenytoin |
| Comments/Corrections | |
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