Document Detail


Mephenytoin hydroxylation in the Cuna Amerindians of Panama.
MedLine Citation:
PMID:  3370193     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1 Mephenytoin p(4')-hydroxylation, which is deficient in 3-5% of Caucasians, was examined in 96 Cuna Amerindians of Panama. 2 Attempts were made to exclude poor compliance with urine collection and ingestion of the drug dose since the assignment of phenotype was based upon urinary recovery of the metabolite. These involved the measurement of the urinary recovery of sparteine, added to the ingested capsule, and of the renal excretion of creatinine. 3 Of the 90 Cunas deemed to be reasonably complaint, none of them appeared to be deficient in p(4')-hydroxylation of mephenytoin.
Authors:
T Inaba; L F Jorge; T D Arias
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  25     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-07-05     Completed Date:  1988-07-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  75-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Faculty of Medicine, University of Toronto, Canada.
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MeSH Terms
Descriptor/Qualifier:
European Continental Ancestry Group
Humans
Hydantoins / metabolism*
Hydroxylation
Indians, Central American*
Mephenytoin / metabolism*,  urine
Panama
Polymorphism, Genetic
Chemical
Reg. No./Substance:
0/Hydantoins; 50-12-4/Mephenytoin
Comments/Corrections

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