Document Detail

Meperidine versus valethamate bromide in shortening the duration of active labor.
MedLine Citation:
PMID:  19664769     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the efficacy and safety of meperidine hydrochloride and valethamate bromide against placebo in shortening the duration of active labor. METHOD: We randomly assigned 160 nulliparous women with a singleton pregnancy at term who needed induction of labor to one of 3 treatments: 50 mg of meperidine (n=53), 16 mg of valethamate bromide (n=53), or a normal saline solution as placebo (n=54). All medications were given by slow intravenous infusion. Labor duration was the main outcome measure. RESULTS: The intervals between infusion and complete cervical dilation and between infusion and delivery were significantly reduced (P<0.001 and P<0.01) in the meperidine group (103.0+/-64.5 minutes and 119.8+/-70.2 minutes), in contrast to the placebo group (173.9+/-74.8 minutes and 192.2+/-82.8 minutes). However, differences were not significant between the 2 treatment groups (139.6+/-63.1 minutes and 160.6+/-71.9 minutes), or between the valethamate bromide and the placebo group. CONCLUSION: Meperidine, but not valethamate bromide, significantly shortened the duration of active labor in nulliparous women with a singleton pregnancy at term.
Bulent Yilmaz; Cavit Kart; Sefa Kelekci; Umut Gokturk; Necdet Sut; Nurten Tarlan; Leyla Mollamahmutoglu
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-08-06
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  107     ISSN:  1879-3479     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-06     Completed Date:  2010-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  126-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health, Education and Research Hospital, Ankara, Turkey.
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MeSH Terms
Analgesics, Opioid / adverse effects,  pharmacology*
Double-Blind Method
Infusions, Intravenous
Labor Stage, First / drug effects
Labor, Induced / methods
Labor, Obstetric / drug effects*
Meperidine / adverse effects,  pharmacology*
Parasympatholytics / adverse effects,  pharmacology
Prospective Studies
Quaternary Ammonium Compounds / adverse effects,  pharmacology*
Time Factors
Young Adult
Reg. No./Substance:
0/Analgesics, Opioid; 0/Parasympatholytics; 0/Quaternary Ammonium Compounds; 57-42-1/Meperidine; 90-22-2/valethamate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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