| Meperidine versus valethamate bromide in shortening the duration of active labor. | |
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MedLine Citation:
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PMID: 19664769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the efficacy and safety of meperidine hydrochloride and valethamate bromide against placebo in shortening the duration of active labor. METHOD: We randomly assigned 160 nulliparous women with a singleton pregnancy at term who needed induction of labor to one of 3 treatments: 50 mg of meperidine (n=53), 16 mg of valethamate bromide (n=53), or a normal saline solution as placebo (n=54). All medications were given by slow intravenous infusion. Labor duration was the main outcome measure. RESULTS: The intervals between infusion and complete cervical dilation and between infusion and delivery were significantly reduced (P<0.001 and P<0.01) in the meperidine group (103.0+/-64.5 minutes and 119.8+/-70.2 minutes), in contrast to the placebo group (173.9+/-74.8 minutes and 192.2+/-82.8 minutes). However, differences were not significant between the 2 treatment groups (139.6+/-63.1 minutes and 160.6+/-71.9 minutes), or between the valethamate bromide and the placebo group. CONCLUSION: Meperidine, but not valethamate bromide, significantly shortened the duration of active labor in nulliparous women with a singleton pregnancy at term. |
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Authors:
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Bulent Yilmaz; Cavit Kart; Sefa Kelekci; Umut Gokturk; Necdet Sut; Nurten Tarlan; Leyla Mollamahmutoglu |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-08-06 |
Journal Detail:
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Title: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Volume: 107 ISSN: 1879-3479 ISO Abbreviation: Int J Gynaecol Obstet Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-06 Completed Date: 2010-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0210174 Medline TA: Int J Gynaecol Obstet Country: Ireland |
Other Details:
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Languages: eng Pagination: 126-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health, Education and Research Hospital, Ankara, Turkey. drbulentyilmaz@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Analgesics, Opioid / adverse effects, pharmacology* Double-Blind Method Female Humans Infusions, Intravenous Labor Stage, First / drug effects Labor, Induced / methods Labor, Obstetric / drug effects* Meperidine / adverse effects, pharmacology* Parasympatholytics / adverse effects, pharmacology Pregnancy Prospective Studies Quaternary Ammonium Compounds / adverse effects, pharmacology* Time Factors Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Parasympatholytics; 0/Quaternary Ammonium Compounds; 57-42-1/Meperidine; 90-22-2/valethamate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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