| Meperidine and normeperidine metabolism in the rhesus monkey. | |
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MedLine Citation:
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PMID: 6151917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Meperidine and its principle metabolite, normeperidine, were given intravenously to four non-human primates prior to cesarean delivery in an equivalent dose for human parturients. The status of the infants regarding neonatal depression was assessed at delivery. Repeated blood samples from both the mother and the neonate were obtained over a period of 4 days. The levels of meperidine and normeperidine were analyzed. The results showed that the metabolism of meperidine and normeperidine in the non-human primate was essentially the same as that observed in the human parturient. In addition, normeperidine appeared to be more toxic than meperidine to the neonate. Finally, there does not appear to be an evidence for neonatal metabolism of meperidine to normeperidine. |
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Authors:
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J C Morrison; S G Douvas; P G Rhodes; R J Christie; E T Bucovaz; W L Wiser |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Volume: 22 ISSN: 0020-7292 ISO Abbreviation: Int J Gynaecol Obstet Publication Date: 1984 Oct |
Date Detail:
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Created Date: 1985-04-15 Completed Date: 1985-04-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0210174 Medline TA: Int J Gynaecol Obstet Country: IRELAND |
Other Details:
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Languages: eng Pagination: 345-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn / metabolism Apgar Score Female Fetus / drug effects Humans Macaca / metabolism* Macaca mulatta / metabolism* Maternal-Fetal Exchange Meperidine / administration & dosage, analogs & derivatives*, metabolism*, toxicity Models, Biological Pregnancy Pregnancy, Animal* Time Factors |
| Chemical | |
Reg. No./Substance:
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57-42-1/Meperidine; 77-17-8/normeperidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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