Document Detail

Meperidine and normeperidine metabolism in the rhesus monkey.
MedLine Citation:
PMID:  6151917     Owner:  NLM     Status:  MEDLINE    
Meperidine and its principle metabolite, normeperidine, were given intravenously to four non-human primates prior to cesarean delivery in an equivalent dose for human parturients. The status of the infants regarding neonatal depression was assessed at delivery. Repeated blood samples from both the mother and the neonate were obtained over a period of 4 days. The levels of meperidine and normeperidine were analyzed. The results showed that the metabolism of meperidine and normeperidine in the non-human primate was essentially the same as that observed in the human parturient. In addition, normeperidine appeared to be more toxic than meperidine to the neonate. Finally, there does not appear to be an evidence for neonatal metabolism of meperidine to normeperidine.
J C Morrison; S G Douvas; P G Rhodes; R J Christie; E T Bucovaz; W L Wiser
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  22     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1985-04-15     Completed Date:  1985-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  345-8     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn / metabolism
Apgar Score
Fetus / drug effects
Macaca / metabolism*
Macaca mulatta / metabolism*
Maternal-Fetal Exchange
Meperidine / administration & dosage,  analogs & derivatives*,  metabolism*,  toxicity
Models, Biological
Pregnancy, Animal*
Time Factors
Reg. No./Substance:
57-42-1/Meperidine; 77-17-8/normeperidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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