Document Detail

Meperidine-induced seizure after revision hip arthroplasty.
MedLine Citation:
PMID:  15188116     Owner:  NLM     Status:  MEDLINE    
Musculoskeletal injuries secondary to seizures are well documented and have a variable incidence. Meperidine (Demerol [Abbott, Abbott Park, IL]) has been used for many years in the postoperative setting for pain control; however, in high doses, it has been associated with seizure. We report the case of patient who experienced a tonic-clonic seizure 5 days after hip revision surgery, resulting in dissociation of the socket from the acetabulum with an associated acetabular fracture. In this patient, meperidine administered for patient-controlled analgesia within recommended range caused the seizure.
Paul E Beaulé; M Iain Smith; Vinh N Nguyen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of arthroplasty     Volume:  19     ISSN:  0883-5403     ISO Abbreviation:  J Arthroplasty     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-09     Completed Date:  2004-10-21     Revised Date:  2005-08-23    
Medline Journal Info:
Nlm Unique ID:  8703515     Medline TA:  J Arthroplasty     Country:  United States    
Other Details:
Languages:  eng     Pagination:  516-9     Citation Subset:  IM    
David Geffen School of Medicine at the University of California Los Angeles, 90017, USA.
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MeSH Terms
Acetabulum / injuries*
Analgesics / adverse effects*
Arthroplasty, Replacement, Hip*
Hip Dislocation / etiology
Meperidine / adverse effects*
Pain / drug therapy
Seizures / chemically induced*,  complications
Reg. No./Substance:
0/Analgesics; 57-42-1/Meperidine
Comment In:
J Arthroplasty. 2005 Apr;20(3):408; author reply 408   [PMID:  15809967 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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