Document Detail

Menthol induces cell-cycle arrest in PC-3 cells by down-regulating G2/M genes, including polo-like kinase 1.
MedLine Citation:
PMID:  22580005     Owner:  NLM     Status:  MEDLINE    
Menthol, a naturally occurring monoterpene, is used in foods, cosmetic products, and topical therapeutic preparations. It also exerts cytotoxic activity against several cancer cell types, including prostate cancer cells. However, little is known about the mechanism of menthol action against prostate cancer cells. In this study, we investigated the effect of menthol on the gene expression profile of PC-3 prostate cancer cells using DNA microarray analyses. Gene set enrichment analysis revealed that menthol primarily affects the expression of cell cycle-related genes. Subsequent experimental analyses validated that menthol induces G2/M arrest. Particularly, menthol markedly down-regulated polo-like kinase 1 (PLK1), a key regulator of G2/M phase progression and inhibited its downstream signaling. Our computational analyses and experimental validation provide a basis for future investigations that are aimed at elucidating the action of menthol on cell cycle control in prostate cancer cells.
Su-Hwa Kim; Sanghoon Lee; Stephen R Piccolo; Kristina Allen-Brady; Eun-Jung Park; Jung Nyeo Chun; Tae Woo Kim; Nam-Hyuk Cho; In-Gyu Kim; Insuk So; Ju-Hong Jeon
Related Documents :
7305625 - Comparative ultrastructural study of the ito cells in the liver in some reptiles.
18505415 - Changing the pathogenetic roadmap of liver fibrosis? where did it start; where will it go?
16749125 - Effect of chloramphenicol on ribonucleic acid synthesis in liver cells in suspension.
17690175 - Flexibility of the hepatic zonation of carbon and nitrogen fluxes linked to lactate and...
15789445 - Identification of cdnas associated with late dedifferentiation in adult newt forelimb r...
25114215 - Wnt ligand/frizzled 2 receptor signaling regulates tube shape and branch-point formatio...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-05-09
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  422     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-11     Completed Date:  2012-08-31     Revised Date:  2012-10-18    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  436-41     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Department of Physiology, Seoul National University College of Medicine, Seoul 110-799, Republic of Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antineoplastic Agents / pharmacology*
Cell Cycle Checkpoints / drug effects*,  genetics
Cell Cycle Proteins / antagonists & inhibitors,  genetics
Cell Division / drug effects*,  genetics
Cell Line, Tumor
G2 Phase / drug effects*,  genetics
Gene Expression / drug effects*
Gene Expression Profiling
Menthol / pharmacology*
Prostatic Neoplasms / genetics*
Protein-Serine-Threonine Kinases / antagonists & inhibitors,  genetics
Proto-Oncogene Proteins / antagonists & inhibitors,  genetics
Grant Support
Reg. No./Substance:
0/Antineoplastic Agents; 0/Cell Cycle Proteins; 0/Proto-Oncogene Proteins; 1490-04-6/Menthol; EC Kinases; EC kinase 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Exploring stemness gene expression and vasculogenic mimicry capacity in well- and poorly differentia...
Next Document:  The evolution of tachykinin/tachykinin receptor (TAC/TACR) in vertebrates and molecular identificati...