Document Detail


Menthol induces cell-cycle arrest in PC-3 cells by down-regulating G2/M genes, including polo-like kinase 1.
MedLine Citation:
PMID:  22580005     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Menthol, a naturally occurring monoterpene, is used in foods, cosmetic products, and topical therapeutic preparations. It also exerts cytotoxic activity against several cancer cell types, including prostate cancer cells. However, little is known about the mechanism of menthol action against prostate cancer cells. In this study, we investigated the effect of menthol on the gene expression profile of PC-3 prostate cancer cells using DNA microarray analyses. Gene set enrichment analysis revealed that menthol primarily affects the expression of cell cycle-related genes. Subsequent experimental analyses validated that menthol induces G2/M arrest. Particularly, menthol markedly down-regulated polo-like kinase 1 (PLK1), a key regulator of G2/M phase progression and inhibited its downstream signaling. Our computational analyses and experimental validation provide a basis for future investigations that are aimed at elucidating the action of menthol on cell cycle control in prostate cancer cells.
Authors:
Su-Hwa Kim; Sanghoon Lee; Stephen R Piccolo; Kristina Allen-Brady; Eun-Jung Park; Jung Nyeo Chun; Tae Woo Kim; Nam-Hyuk Cho; In-Gyu Kim; Insuk So; Ju-Hong Jeon
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-05-09
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  422     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-11     Completed Date:  2012-08-31     Revised Date:  2012-10-18    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  436-41     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Physiology, Seoul National University College of Medicine, Seoul 110-799, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / pharmacology*
Cell Cycle Checkpoints / drug effects*,  genetics
Cell Cycle Proteins / antagonists & inhibitors,  genetics
Cell Division / drug effects*,  genetics
Cell Line, Tumor
Down-Regulation
G2 Phase / drug effects*,  genetics
Gene Expression / drug effects*
Gene Expression Profiling
Humans
Male
Menthol / pharmacology*
Prostatic Neoplasms / genetics*
Protein-Serine-Threonine Kinases / antagonists & inhibitors,  genetics
Proto-Oncogene Proteins / antagonists & inhibitors,  genetics
Grant Support
ID/Acronym/Agency:
5T32CA093247/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Cell Cycle Proteins; 0/Proto-Oncogene Proteins; 1490-04-6/Menthol; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.1/polo-like kinase 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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