Document Detail

Mental stress may induce QT-interval prolongation and T-wave notching.
MedLine Citation:
PMID:  17617071     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The effects of active and passive mental stress (PMS) on the QT interval were studied by using an intraindividual regression method of QT-interval correction for heart rate. METHODS: Thirty healthy males (age 21.2 +/- 1.8 years) performed a mental arithmetic for 1 minute, which was considered as active mental stress (AMS) because of the performance requirement. A 1-minute unpleasant video clip was used for PMS. Two baseline and two (an early and a late) ECGs were prepared in both mental stress periods. The individual QT-RR relationship was assessed by linear regression analysis of 7-15 (11.0 +/- 1.9) controlled QT-RR data pairs, also obtained from ECGs gained during a successive set of 9 isometric stretching exercises. RESULTS: Heart rate has increased significantly at both measurements in response to AMS (P < 0.0001), but not in response to passive stress. QTc significantly prolonged early in AMS (P = 0.0004), then normalized by the end of the period. During PMS, no significant QTc changes were observed. The evolution of bifid T waves was noted in 14 subjects: 8 presented bifid T waves during both AMS and exercise, and 6 during only exercise. CONCLUSIONS: AMS and PMS elicit different cardiovascular reactions. Our results indicate that changes in the autonomic tone, probably abrupt sympathetic predominance, may cause QTc prolongation and bifid T waves. This suggests that besides stress quality and intensity, the dynamics of stress application and perception also influence repolarization.
Gábor Andrássy; Attila Szabo; Gyöngyvér Ferencz; Zsófia Trummer; Eszter Simon; Adám Tahy
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc     Volume:  12     ISSN:  1082-720X     ISO Abbreviation:  Ann Noninvasive Electrocardiol     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-09     Completed Date:  2007-09-27     Revised Date:  2008-03-10    
Medline Journal Info:
Nlm Unique ID:  9607443     Medline TA:  Ann Noninvasive Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  251-9     Citation Subset:  IM    
Department of Cardiology, Saint Francis Hospital, Budapest, Hungary.
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MeSH Terms
Exercise Test
Heart Rate / physiology
Long QT Syndrome / physiopathology*
Stress, Psychological / physiopathology*

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