| Mental stress-induced myocardial ischemia in coronary artery disease patients with left ventricular dysfunction. | |
| | |
MedLine Citation:
|
PMID: 17556164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Reduced left ventricular ejection fraction (LVEF) is a risk factor for poor outcomes in patients with coronary artery disease (CAD). Mental stress-induced myocardial ischemia (MSIMI) also identifies a subset of CAD patients at increased risk for future cardiovascular events. Susceptibility to MSIMI in patients with CAD and reduced LVEF is unknown. METHODS AND RESULTS: We enrolled 182 patients (67 women) with a mean age of 64 years and a documented history of CAD in this study. Baseline resting ejection fraction was determined by use of technetium 99m sestamibi gated single photon emission computed tomography. Abnormal LVEF was defined as less than 45% for men and less than 50% for women (based on published norms for our software [Cedars-Sinai Medical Center]). All participants underwent mental stress testing with a public speaking task. Rest/stress myocardial perfusion single photon emission computed tomography was performed via conventional methodology. Images were visually compared for number and severity of perfusion defects by use of a scoring method from 0 to 4. A summed difference score was calculated as the difference between summed stress and rest scores. A score of greater than 3 was considered abnormal. MSIMI developed in 19% of patients with normal LVEF and 31% of those with reduced LVEF. There is no statistically significant difference between the two groups (P = .11). CONCLUSIONS: CAD patients with left ventricular dysfunction are equally susceptible to MSIMI as those with normal LVEF. |
| | |
Authors:
|
Mustafa Hassan; Kaki M York; Haihong Li; Qin Li; David S Sheps |
Related Documents
:
|
3731454 - Lactate dehydrogenase isoenzymes in serum during unstable angina. 981094 - Acute coronary insufficiency with normal coronary arteriograms. 308334 - Aspirin- and coumadin-related bleeding after coronary- artery bypass graft surgery. 7446424 - Ergonovine testing in a coronary care unit. 15190534 - Attenuated respiratory modulation of chemoreflex-mediated sympathoexcitation in patient... 6783684 - Intravenous carbon dioxide as an echocardiographic contrast agent. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2007-04-16 |
Journal Detail:
|
Title: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology Volume: 14 ISSN: 1532-6551 ISO Abbreviation: J Nucl Cardiol Publication Date: 2007 May-Jun |
Date Detail:
|
Created Date: 2007-06-08 Completed Date: 2007-07-05 Revised Date: 2007-12-03 |
Medline Journal Info:
|
Nlm Unique ID: 9423534 Medline TA: J Nucl Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 308-13 Citation Subset: IM |
Affiliation:
|
Cardiovascular Research, Division of Cardiology, Department of Medicine, University of Florida, Gainesville, FL, USA. mustafa.hassan@medicine.ufl.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Causality Comorbidity Female Florida / epidemiology Humans Incidence Male Middle Aged Myocardial Ischemia / diagnosis, epidemiology*, psychology* Risk Assessment / methods* Stress, Psychological / diagnosis, epidemiology*, psychology* Ventricular Dysfunction, Left / diagnosis, epidemiology*, psychology* |
| Grant Support | |
ID/Acronym/Agency:
|
HL 070265/HL/NHLBI NIH HHS; HL 072059/HL/NHLBI NIH HHS |
| Comments/Corrections | |
Comment In:
|
J Nucl Cardiol. 2007 May-Jun;14(3):269-71
[PMID:
17556157
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evaluation of left ventricular mechanical dyssynchrony as determined by phase analysis of ECG-gated ...
Next Document: CT-based attenuation correction versus prone imaging to decrease equivocal interpretations of rest/s...