| Mental deterioration in old age: results of two multicenter, clinical trials with nimodipine. The Nimodipine Study Group. | |
| | |
MedLine Citation:
|
PMID: 8519047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The efficacy and tolerability of nimodipine, a calcium antagonist selective for the central nervous system, was evaluated in old age dementias in two multicenter, clinical trials. A total of 755 elderly patients suffering from mental deterioration of degenerative or vascular origin were enrolled in the studies. In the first study, 352 patients received nimodipine 30 mg TID orally for 3 months; in the second study, 403 patients received the same treatment for 6 months. In both studies, psychobehavioral instruments showed a highly significant improvement of the global functional state. In hypertensive patients, nimodipine had a synergistic effect with the antihypertensive drugs. These results confirm the therapeutic efficacy and safety of nimodipine in the treatment of old age dementias. |
| | |
Authors:
|
L Parnetti; U Senin; M Carosi; H Baasch |
Related Documents
:
|
16760697 - Prognosis and mechanism of death in treated heart failure: data from the placebo arm of... 16211207 - Carvedilol improves myocardial contractility compared with metoprolol in patients with ... 134897 - Long-term treatment with beta-blockers after myocardial infarction. 9839297 - Treatment of hypertension after renal transplantation: long-term efficacy of verapamil,... 17130317 - Pneumatic pump reduces leg wound complications in cardiac patients. 10922087 - Is prophylactic ciprofloxacin effective in delaying biliary stent blockage? |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
|
Title: Clinical therapeutics Volume: 15 ISSN: 0149-2918 ISO Abbreviation: Clin Ther Publication Date: 1993 Mar-Apr |
Date Detail:
|
Created Date: 1993-07-26 Completed Date: 1993-07-26 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7706726 Medline TA: Clin Ther Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 394-406 Citation Subset: IM |
Affiliation:
|
Institute of Gerontology and Geriatrics, University of Perugia, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Activities of Daily Living Aged Aged, 80 and over Dementia / drug therapy*, psychology Dementia, Vascular / drug therapy, psychology Female Humans Interpersonal Relations Male Memory / drug effects Mental Processes / drug effects Nimodipine / adverse effects, therapeutic use* Psychiatric Status Rating Scales Psychomotor Performance / drug effects |
| Chemical | |
Reg. No./Substance:
|
66085-59-4/Nimodipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of cimetidine and ranitidine on the pharmacokinetics of a chronotherapeutically formulated o...
Next Document: Use of a prefilled insulin syringe (Novolin Prefilled) by patients with diabetes.