Document Detail

Mental deterioration in old age: results of two multicenter, clinical trials with nimodipine. The Nimodipine Study Group.
MedLine Citation:
PMID:  8519047     Owner:  NLM     Status:  MEDLINE    
The efficacy and tolerability of nimodipine, a calcium antagonist selective for the central nervous system, was evaluated in old age dementias in two multicenter, clinical trials. A total of 755 elderly patients suffering from mental deterioration of degenerative or vascular origin were enrolled in the studies. In the first study, 352 patients received nimodipine 30 mg TID orally for 3 months; in the second study, 403 patients received the same treatment for 6 months. In both studies, psychobehavioral instruments showed a highly significant improvement of the global functional state. In hypertensive patients, nimodipine had a synergistic effect with the antihypertensive drugs. These results confirm the therapeutic efficacy and safety of nimodipine in the treatment of old age dementias.
L Parnetti; U Senin; M Carosi; H Baasch
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical therapeutics     Volume:  15     ISSN:  0149-2918     ISO Abbreviation:  Clin Ther     Publication Date:    1993 Mar-Apr
Date Detail:
Created Date:  1993-07-26     Completed Date:  1993-07-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7706726     Medline TA:  Clin Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  394-406     Citation Subset:  IM    
Institute of Gerontology and Geriatrics, University of Perugia, Italy.
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MeSH Terms
Activities of Daily Living
Aged, 80 and over
Dementia / drug therapy*,  psychology
Dementia, Vascular / drug therapy,  psychology
Interpersonal Relations
Memory / drug effects
Mental Processes / drug effects
Nimodipine / adverse effects,  therapeutic use*
Psychiatric Status Rating Scales
Psychomotor Performance / drug effects
Reg. No./Substance:

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