Document Detail

Menstrual and reproductive risk factors and risk for gastric adenocarcinoma in women: findings from the canadian national enhanced cancer surveillance system.
MedLine Citation:
PMID:  16843679     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The role of menstrual and reproductive risk factors for gastric cancer has not been well studied. METHODS: This population-based case-control study included 326 women aged 20 to 74 years with gastric adenocarcinoma. Controls were 326 women frequency matched on age. Data for reproductive and/or hormonal exposure and gastric cancer risk factors were captured through self-administered questionnaire. RESULTS: Later age at menarche was associated with increased risk for adenocarcinoma compared with menarche onset at younger than 13 years of age (13 to 14 years: odds ratio [OR], 1.45; 95% confidence interval [CI], 1.00-2.10; > or =15 years: OR, 1.93; 95% CI, 1.19-3.13). Compared with premenopause, natural menopause was associated with increased risk for adenocarcinoma (OR, 1.99; 95% CI, 0.98-4.05). Compared with nulliparity, 4 or more births were associated with decreased risk for gastric cancer, as was being pregnant for 5 months or longer if the first pregnancy occurred at younger than 24 years (OR, 0.55; 95% CI, 0.31-0.96) or 25 years or older (OR, 0.67; 95% CI, 0.38-1.18). Oral contraceptives and hormone replacement therapy were associated with a non-statistically significant decreased risk. CONCLUSION: These findings suggest that hormonal factors associated with greater exposure to estrogen and/or progesterone may be associated with decreased risk for gastric cancer.
Sarah Frise; Nancy Kreiger; Steven Gallinger; George Tomlinson; Michelle Cotterchio
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-07-13
Journal Detail:
Title:  Annals of epidemiology     Volume:  16     ISSN:  1047-2797     ISO Abbreviation:  Ann Epidemiol     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-02-20     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  9100013     Medline TA:  Ann Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  908-16     Citation Subset:  IM    
Drug Safety Department, AstraZeneca, Mississauga, Toronto, Ontario, Canada.
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MeSH Terms
Adenocarcinoma / epidemiology*,  etiology
Canada / epidemiology
Case-Control Studies
Contraceptives, Oral, Hormonal / adverse effects
Hormone Replacement Therapy / adverse effects
Logistic Models
Menstrual Cycle*
Middle Aged
Risk Factors
Stomach Neoplasms / epidemiology*,  etiology
Reg. No./Substance:
0/Contraceptives, Oral, Hormonal
Comment In:
Ann Epidemiol. 2007 Sep;17(9):721-2   [PMID:  17553698 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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