Document Detail

Menstrual and reproductive factors in women, genetic variation in CYP17A1, and pancreatic cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort.
MedLine Citation:
PMID:  23015357     Owner:  NLM     Status:  MEDLINE    
Menstrual and reproductive factors and exogenous hormone use have been investigated as pancreatic cancer risk factors in case-control and cohort studies, but results have been inconsistent. We conducted a prospective examination of menstrual and reproductive factors, exogenous hormone use and pancreatic cancer risk (based on 304 cases) in 328,610 women from the EPIC cohort. Then, in a case-control study nested within the EPIC cohort, we examined 12 single nucleotide polymorphisms (SNPs) in CYP17A1 (an essential gene in sex steroid metabolism) for association with pancreatic cancer in women and men (324 cases and 353 controls). Of all factors analyzed, only younger age at menarche (<12 vs. 13 years) was moderately associated with an increased risk of pancreatic cancer in the full cohort; however, this result was marginally significant (HR = 1.44; 95% CI = 0.99-2.10). CYP17A1 rs619824 was associated with HRT use (p value = 0.037) in control women; however, none of the SNPs alone, in combination, or as haplotypes were associated with pancreatic cancer risk. In conclusion, with the possible exception of an early age of menarche, none of the menstrual and reproductive factors, and none of the 12 common genetic variants we evaluated at the CYP17A1 locus makes a substantial contribution to pancreatic cancer susceptibility in the EPIC cohort.
Eric J Duell; Noémie Travier; Leila Lujan-Barroso; Laure Dossus; Marie-Christine Boutron-Ruault; Françoise Clavel-Chapelon; Rosario Tumino; Giovanna Masala; Vittorio Krogh; Salvatore Panico; Fulvio Ricceri; Maria Luisa Redondo; Miren Dorronsoro; Esther Molina-Montes; José M Huerta; Aurelio Barricarte; Kay-Tee Khaw; Nick J Wareham; Naomi E Allen; Ruth Travis; Peter D Siersema; Petra H M Peeters; Antonia Trichopoulou; Eirini Fragogeorgi; Eleni Oikonomou; Heiner Boeing; Madlen Schuetze; Federico Canzian; Annekatrin Lukanova; Anne Tjønneland; Nina Roswall; Kim Overvad; Elisabete Weiderpass; Inger Torhild Gram; Eiliv Lund; Björn Lindkvist; Dorthe Johansen; Weimin Ye; Malin Sund; Veronika Fedirko; Mazda Jenab; Dominique S Michaud; Elio Riboli; H Bas Bueno-de-Mesquita
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-30
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  132     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-02-19     Completed Date:  2013-05-07     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2164-75     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 UICC.
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MeSH Terms
Adenocarcinoma / etiology*
Case-Control Studies
Follow-Up Studies
Haplotypes / genetics
Middle Aged
Neoplasm Staging
Pancreatic Neoplasms / etiology*
Polymorphism, Single Nucleotide / genetics*
Prospective Studies
Reproductive History
Risk Factors
Steroid 17-alpha-Hydroxylase / genetics*
Grant Support
G0401527//Medical Research Council; G1000143//Medical Research Council; MC_U106179471//Medical Research Council; //British Heart Foundation; //Cancer Research UK; //Department of Health; //Medical Research Council; //Wellcome Trust
Reg. No./Substance:
EC protein, human; EC 17-alpha-Hydroxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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