| Menstrual and reproductive factors in women, genetic variation in CYP17A1, and pancreatic cancer risk in the european prospective investigation into cancer and nutrition (EPIC) cohort. | |
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MedLine Citation:
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PMID: 23015357 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Menstrual and reproductive factors and exogenous hormone use have been investigated as pancreatic cancer risk factors in case-control and cohort studies, but results have been inconsistent. We conducted a prospective examination of menstrual and reproductive factors, exogenous hormone use, and pancreatic cancer risk (based on 304 cases) in 328,610 women from the EPIC cohort. Then, in a case-control study nested within the EPIC cohort, we examined 12 single nucleotide polymorphisms (SNPs) in CYP17A1 (an essential gene in sex steroid metabolism) for association with pancreatic cancer in women and men (324 cases and 353 controls). Of all factors analysed, only younger age at menarche (<12 vs 13 yrs) was moderately associated with an increased risk of pancreatic cancer in the full cohort; however, this result was marginally significant (HR=1.44; 95% CI=0.99-2.10). CYP17A1 rs619824 was associated with HRT use (P-value=0.037) in control women; however, none of the SNPs alone, in combination, or as haplotypes were associated with pancreatic cancer risk. In conclusion, with the possible exception of an early age of menarche, none of the menstrual and reproductive factors, and none of the 12 common genetic variants we evaluated at the CYP17A1 locus makes a substantial contribution to pancreatic cancer susceptibility in the EPIC cohort. © 2012 Wiley Periodicals, Inc. |
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Authors:
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Eric J Duell; Noémie Travier; Leila Lujan-Barroso; Laure Dossus; Marie-Christine Boutron-Ruault; Françoise Clavel-Chapelon; Rosario Tumino; Giovanna Masala; Vittorio Krogh; Salvatore Panico; Fulvio Ricceri; Maria Luisa Redondo; Miren Dorronsoro; Esther Molina-Montes; José M Huerta; Aurelio Barricarte; Kay-Tee Khaw; Nick J Wareham; Naomi E Allen; Ruth Travis; Peter D Siersema; Petra Hm Peeters; Antonia Trichopoulou; Eirini Fragogeorgi; Eleni Oikonomou; Heiner Boeing; Madlen Schuetze; Federico Canzian; Annekatrin Lukanova; Anne Tjønneland; Nina Roswall; Kim Overvad; Elisabete Weiderpass; Inger Torhild Gram; Eiliv Lund; Björn Lindkvist; Dorthe Johansen; Weimin Ye; Malin Sund; Veronika Fedirko; Mazda Jenab; Dominique S Michaud; Elio Riboli; H Bas Bueno-de-Mesquita |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-27 |
Journal Detail:
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Title: International journal of cancer. Journal international du cancer Volume: - ISSN: 1097-0215 ISO Abbreviation: Int. J. Cancer Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 UICC. |
Affiliation:
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Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain. eduell@iconcologia.net. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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