Document Detail


Menstrual pain: its origin and pathogenesis.
MedLine Citation:
PMID:  7001019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A variety of misconceptions about the etiology of dysmenorrhea have existed in the past. Experimental and clinical research of the last 15 years, however, has identified uterine prostaglandins as substantially contributing to the pathogenesis of primary dysmenorrhea. This paper reviews the various current theories of pathogenicity. It is now known that at the end of the menstrual cycle, prostaglandins increase myometrial contractions and cause constriction of small endometrial blood vessels, with consequent tissue ischemia, endometrial disintegration, bleeding and pain. Dysmenorrhea may be due to tissue ischemia resulting from increased intrauterine pressure, vessel constriction and decreased uterine blood flow. The most compelling evidence for the "prostaglandin theory" is the success of prostaglandin synthesis inhibitors in the treatment of dysmenorrhea. The pain relief achieved with these drugs is accompanied by a suppression of prostaglandin synthesis and a decrease in intrauterine pressure.
Authors:
Z Rosenwaks; G Seegar-Jones
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  25     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  1980 Oct 
Date Detail:
Created Date:  1981-01-29     Completed Date:  1981-01-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  207-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Chemical Phenomena
Chemistry
Dysmenorrhea / etiology*,  physiopathology
Estrogens / physiology
Female
Humans
Myometrium / physiopathology
Pregnancy
Progestins / physiology
Prostaglandins / biosynthesis,  physiology
Uterine Cervical Diseases / complications
Uterine Contraction
Uterus / innervation
Chemical
Reg. No./Substance:
0/Estrogens; 0/Progestins; 0/Prostaglandins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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