Document Detail

Menstrual pain: its origin and pathogenesis.
MedLine Citation:
PMID:  7001019     Owner:  NLM     Status:  MEDLINE    
A variety of misconceptions about the etiology of dysmenorrhea have existed in the past. Experimental and clinical research of the last 15 years, however, has identified uterine prostaglandins as substantially contributing to the pathogenesis of primary dysmenorrhea. This paper reviews the various current theories of pathogenicity. It is now known that at the end of the menstrual cycle, prostaglandins increase myometrial contractions and cause constriction of small endometrial blood vessels, with consequent tissue ischemia, endometrial disintegration, bleeding and pain. Dysmenorrhea may be due to tissue ischemia resulting from increased intrauterine pressure, vessel constriction and decreased uterine blood flow. The most compelling evidence for the "prostaglandin theory" is the success of prostaglandin synthesis inhibitors in the treatment of dysmenorrhea. The pain relief achieved with these drugs is accompanied by a suppression of prostaglandin synthesis and a decrease in intrauterine pressure.
Z Rosenwaks; G Seegar-Jones
Related Documents :
1539699 - Right and left ventricular function in fetal sheep exposed to long-term high-altitude h...
23916619 - Foot pressure pattern and its correlation with knee range of motion limitations for ind...
2651699 - Hemodynamic validation of doppler assessment of fetoplacental circulation in a sheep mo...
4036999 - Effects of hypoxemic events on breathing, body movements, and heart rate variation: a s...
4050919 - Electrical and mechanical uterine activity and gap junctions in peripartal sheep.
7001019 - Menstrual pain: its origin and pathogenesis.
7965879 - Pressure redistribution by molded inserts in diabetic footwear: a pilot study.
3558199 - Thoracic pressure and nasal patency.
2846689 - The in vivo production of peptide leukotrienes after pulmonary anaphylaxis in the rat.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  25     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  1980 Oct 
Date Detail:
Created Date:  1981-01-29     Completed Date:  1981-01-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  207-12     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Chemical Phenomena
Dysmenorrhea / etiology*,  physiopathology
Estrogens / physiology
Myometrium / physiopathology
Progestins / physiology
Prostaglandins / biosynthesis,  physiology
Uterine Cervical Diseases / complications
Uterine Contraction
Uterus / innervation
Reg. No./Substance:
0/Estrogens; 0/Progestins; 0/Prostaglandins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Nutritional effects of oral contraceptive use: a review.
Next Document:  A rationale for the treatment of dysmenorrhea.