| Menstrual cycle-related sialidase activity of the female cervical mucus is associated with exosome-like vesicles. | |
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MedLine Citation:
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PMID: 17562335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study endogenous sialidase activity in genital tract secretions of pregnant and nonpregnant women. DESIGN: Laboratory study. SETTING: Department of Evolutionary Biology and Department of Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy. INTERVENTION(S): Vaginal and cervical mucus samples were obtained from pregnant and nonpregnant women in different phases of the menstrual cycle and in different weeks of pregnancy. MAIN OUTCOME MEASURE(S): Sialidase activity was assessed by fluorimetric assay and localized by transmission electron microscopy and differential centrifugation. RESULT(S): Sialidase activity in cervical mucus of healthy women reaches a maximum in the ovulatory phase. Cervical mucus from pregnant and nonpregnant women had significant sialidase activity that was associated with membranous vesicles having an exosome-like structure. CONCLUSION(S): Female cervical mucus contains an endogenous menstrual cycle-related sialidase that could be involved in modifying the rheologic properties of mucus to favor sperm progression at fertilization. Its association with exosome-like vesicles also suggests a role in intercellular communication before and after fertilization. |
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Authors:
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Federica Flori; Federica Secciani; Antonietta Capone; Eugenio Paccagnini; Sabrina Caruso; Maria Grazia Ricci; Riccardo Focarelli |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-06-11 |
Journal Detail:
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Title: Fertility and sterility Volume: 88 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-09 Completed Date: 2007-10-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1212-9 Citation Subset: IM |
Affiliation:
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Department of Evolutionary Biology, University of Siena, Policlinico le Scotte, Siena, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cervix Mucus / enzymology* Cytoplasmic Vesicles / enzymology* Female Humans Menstrual Cycle / metabolism* Middle Aged Neuraminidase / metabolism* Pregnancy |
| Chemical | |
Reg. No./Substance:
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EC 3.2.1.18/Neuraminidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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