| Menstrual cycle elicits divergent forearm vascular responses to vestibular activation in humans. | |
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MedLine Citation:
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PMID: 19939746 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The menstrual cycle has been reported to alter mean arterial pressure (MAP), but not muscle sympathetic nerve activity (MSNA), during vestibular activation. Specifically, MAP responses to head-down rotation (HDR) are augmented during the mid-luteal (ML) phase compared to the early follicular (EF) phase in young, eumenorrheic women. The purpose of the present study was to determine if the menstrual cycle influences vestibular-mediated changes in limb blood flow. MSNA, MAP, heart rate, and limb blood flow responses to HDR were measured in 12 healthy women. Resting MSNA, MAP, heart rate, forearm blood flow and calf blood flow were not altered by the menstrual cycle. HDR elicited similar increases in MSNA during the EF (Delta3+/-1 bursts/min; P<0.05) and ML (Delta2+/-1 bursts/min; P<0.05) phase, but only increased MAP during the ML phase (Delta4+/-2 mmHg; P<0.05). HDR did not change heart rate during either the EF or ML phase. HDR elicited similar increases in calf vascular resistance during the EF (Delta6+/-2 mmHg/mL/100 mL/min; P<0.05) and ML (Delta7+/-2 mmHg/mL/100mL/min; P<0.05) phases of the menstrual cycle. In contrast, HDR increased forearm vascular resistance during the ML phase (Delta4+/-2 mmHg/mL/100mL/min; P<0.05), but not the EF phase (Delta0+/-2 mmHg/mL/100mL/min). These findings suggest an increased transduction of sympathetic nerve activity into forearm vascular resistance during the ML phase, and reveal the first recorded divergent vascular response to vestibular excitation in human limbs. |
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Authors:
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Johnathan E Lawrence; Jenna C Klein; Jason R Carter |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-11-24 |
Journal Detail:
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Title: Autonomic neuroscience : basic & clinical Volume: 154 ISSN: 1872-7484 ISO Abbreviation: Auton Neurosci Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-24 Completed Date: 2010-06-22 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 100909359 Medline TA: Auton Neurosci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 89-93 Citation Subset: IM |
Copyright Information:
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2009 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Exercise Science, Health and Physical Education, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Blood Pressure / physiology* Blood Vessels / physiology* Female Forearm / blood supply, innervation* Head-Down Tilt / physiology Heart Rate / physiology Humans Menstrual Cycle / physiology* Peroneal Nerve / physiology Vestibule, Labyrinth / physiology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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HL-088689/HL/NHLBI NIH HHS; R15 HL088689-01A1/HL/NHLBI NIH HHS |
| Comments/Corrections | |
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