| Menstrual blood loss measurement: validation of the alkaline hematin technique for feminine hygiene products containing superabsorbent polymers. | |
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MedLine Citation:
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PMID: 20447631 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To validate the alkaline hematin technique for measurement of menstrual blood loss using ultra-thin sanitary towels that contain superabsorbent polymer granules as the absorptive agent. DESIGN: Laboratory study using simulated menstrual fluid (SMF) and Always Ultra Normal, Long, and Night "with wings" sanitary towels. SETTING: Keele Menstrual Disorders Laboratory. PATIENT(S): None. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Recovery of blood, linearity, and interassay variation over a range of SMF volumes applied to towels. Because of the variable percentage of blood in menstrual fluid, blood recovery was assessed from SMF constituted as 10%, 25%, 50%, and 100% blood. The lower limit of reliable detection and the effect of storing soiled towels for up to 4 weeks at 15°C-20°C, 4°C, and -20°C before analysis were determined. RESULT(S): Ninety percent recovery was reproducibly achieved up to 30 mL applied volume at all tested SMF compositions, except at low volume or high dilution equivalent to <2 mL whole blood. Samples could be stored for 3 weeks at all tested temperatures without loss of recovery. The technique was suitable for processing towels individually or in batches. CONCLUSION(S): The alkaline hematin technique is a suitable and validated method for measuring menstrual blood loss from Always Ultra sanitary towels that contain superabsorbent polymers. |
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Authors:
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Julia L Magnay; Tracy M Nevatte; Vandana Dhingra; Shaughn O'Brien |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Validation Studies Date: 2010-05-05 |
Journal Detail:
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Title: Fertility and sterility Volume: 94 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-26 Completed Date: 2011-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 2742-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Institute for Science and Technology in Medicine, Guy Hilton Research Centre, Hartshill, Stoke on Trent, United Kingdom. j.l.magnay@bemp.keele.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorbent Pads*
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standards Adsorption Blood / metabolism Blood Physiological Phenomena / drug effects Calibration Drug Stability Female Hemin / chemistry* Humans Hydrogen-Ion Concentration Linear Models Menstrual Hygiene Products* / standards Menstruation / blood, physiology* Polymers / chemistry, pharmacokinetics, pharmacology* Time Factors Uterine Hemorrhage / pathology |
| Chemical | |
Reg. No./Substance:
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0/Polymers; 16009-13-5/Hemin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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