Document Detail

Menstrual abnormalities and predisposition to pregnancy-related hypertensive disorders: a retrospective study.
MedLine Citation:
PMID:  20170353     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Pregnancy-related hypertensive disorders (PRHDs) are a leading cause of maternal and perinatal morbidity and mortality in developed countries. This study investigated a possible association of PRHDs with menstrual abnormalities. MATERIALS AND METHODS: We contacted all women with PRHDs who delivered in our clinic between 2004 and 2007 as well as a random control cohort without pregnancy complications and asked them about their menstrual cycle characteristics. Statistical analyses were performed using R, with significance set at p < 0.05. RESULTS: We collected data for 237 women with normal pregnancies and 255 women with PRHDs, among whom 143 had gestational hypertension and 70 had mild and 41 severe preeclampsia. By monovariate analysis, PRHDs correlated with dysmenorrhoea, hypermenorrhoea and menstrual irregularity (p < 0.05). By multivariate analysis, the occurrence of PRHDs was influenced by dysmenorrhoea and menstrual irregularity (p < 0.05). CONCLUSIONS: PRHDs usually affect women with painful or irregular menstrual cycles, perhaps due to metabolic syndrome or molecular pathways involving vasoactive substances, with clear vascular implications.
Arrigo Fruscalzo; Serena Bertozzi; Ambrogio P Londero; Anna Biasioli; Lorenza Driul; Ludwig Kiesel; Diego Marchesoni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  26     ISSN:  1473-0766     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-06     Completed Date:  2010-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  445-50     Citation Subset:  IM    
Frauenklinik, Universitaetsklinikum Muenster, Germany.
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MeSH Terms
Hypertension, Pregnancy-Induced / epidemiology*
Menstrual Cycle
Menstruation Disturbances / epidemiology*
Predictive Value of Tests
Retrospective Studies

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