Document Detail


Men's body mass index in relation to embryo quality and clinical outcomes in couples undergoing in vitro fertilization.
MedLine Citation:
PMID:  22884013     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the association between men's body mass index (BMI), early embryo quality, and clinical outcomes in couples undergoing in vitro fertilization (IVF).
DESIGN: Prospective cohort study.
SETTING: Fertility clinic in an academic medical center.
PATIENT(S): 114 couples who underwent 172 assisted reproduction cycles.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Fertilization rate, embryo quality, implantation rate, clinical pregnancy rate, and live birth rate.
RESULT(S): The fertilization rate was higher among obese men than among normal weight men in conventional IVF cycles. No statistically significant associations were found between men's BMI and the proportion of poor-quality embryos on day 3, slow embryo cleavage rate, or accelerated embryo cleavage rate. Men's BMI was unrelated to positive β-human chorionic gonadotropin rate, clinical pregnancy rate, or live-birth rate per embryo transfer. Among couples undergoing intracytoplasmic sperm injection, the odds of live birth in couples with obese male partners was 84% lower than the odds in couples with men with normal BMI.
CONCLUSION(S): Our data suggest a possible deleterious effect of male obesity on the odds of having a live birth among couples undergoing intracytoplasmic sperm injection.
Authors:
Daniela S Colaci; Myriam Afeiche; Audrey J Gaskins; Diane L Wright; Thomas L Toth; Cigdem Tanrikut; Russ Hauser; Jorge E Chavarro
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Video-Audio Media     Date:  2012-08-09
Journal Detail:
Title:  Fertility and sterility     Volume:  98     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-22     Completed Date:  2013-01-03     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1193-9.e1     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, Massachusetts 02115, USA. dcolaci@hsph.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Academic Medical Centers
Adult
Body Mass Index*
Boston
Embryo Implantation
Embryo Transfer
Embryo, Mammalian / pathology*
Female
Fertilization in Vitro* / adverse effects
Humans
Infertility / complications,  physiopathology,  therapy*
Linear Models
Live Birth
Logistic Models
Male
Obesity / complications*,  physiopathology
Odds Ratio
Pregnancy
Pregnancy Rate
Prospective Studies
Risk Assessment
Risk Factors
Sex Factors
Sperm Injections, Intracytoplasmic* / adverse effects
Treatment Outcome
Grant Support
ID/Acronym/Agency:
DK46200/DK/NIDDK NIH HHS; ES000002/ES/NIEHS NIH HHS; ES009718/ES/NIEHS NIH HHS; P30 DK046200/DK/NIDDK NIH HHS; P30 ES000002/ES/NIEHS NIH HHS; R01 ES009718/ES/NIEHS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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