Document Detail

Menopausal status influences ambulatory blood pressure levels and blood pressure changes during mental stress.
MedLine Citation:
PMID:  8252693     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Frequent and large cardiovascular and neuroendocrine responses to psychological stress are thought to enhance an individual's risk for cardiovascular diseases. Preliminary data suggest that levels of reproductive hormones affect the magnitude of stress responses, perhaps contributing to the protective effect of ovarian hormones on premenopausal women's rates of coronary heart disease. METHODS AND RESULTS: Healthy middle-aged men and premenopausal and postmenopausal women performed a series of standardized mental and physical challenges while blood pressure, heart rate, plasma catecholamines, lipids, and lipoproteins were measured. Subjects then wore an ambulatory blood pressure monitor during two consecutive workdays. Results showed that postmenopausal women had larger mean +/- SEM stress-induced increases in systolic blood pressure (24.7 +/- 2.2 mm Hg) and diastolic blood pressure (14.3 +/- 1.0 mm Hg) compared with either premenopausal women (16.9 +/- 1.3 and 10.2 +/- 0.9 mm Hg) or men (17.7 +/- 1.5 and 10.9 +/- 1.1 mm Hg, respectively). Postmenopausal women and men had higher mean +/- SEM ambulatory diastolic blood pressure levels (75.5 +/- 3.2 and 76.4 +/- 1.8 mm Hg) than did premenopausal women (69.9 +/- 2.2 mm Hg). Large blood pressure responses during public speaking were associated with high cholesterol levels and low educational attainment. CONCLUSIONS: Menopause is associated with enhanced stress-induced cardiovascular responses and elevated ambulatory blood pressure during the workday. These effects may contribute to the risk of cardiovascular morbidity and mortality after the menopause.
J F Owens; C M Stoney; K A Matthews
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  88     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-01-13     Completed Date:  1994-01-13     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2794-802     Citation Subset:  AIM; IM    
Department of Psychiatry, University of Pittsburgh School of Medicine Pa.
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MeSH Terms
Blood Pressure / physiology*
Coronary Disease / etiology
Educational Status
Epinephrine / blood
Gonadal Steroid Hormones / blood
Heart Rate
Lipids / blood
Menopause / blood,  physiology*,  psychology*
Middle Aged
Norepinephrine / blood
Risk Factors
Stress, Psychological / blood,  physiopathology*
Grant Support
Reg. No./Substance:
0/Gonadal Steroid Hormones; 0/Lipids; 51-41-2/Norepinephrine; 51-43-4/Epinephrine
Comment In:
Circulation. 1994 Jun;89(6):2947   [PMID:  8205718 ]

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