Document Detail


Menopausal status and haemostatic variables.
MedLine Citation:
PMID:  6129369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The incidence of ischaemic heart disease (IHD) is higher in postmenopausal women than in premenopausal women of the same age. The difference may be partly explicable in terms of differences between premenopausal and postmenopausal women in haemostatic function. This possibility has been studied in 833 White women in the Northwick Park Heart Study (NPHS). Mean levels of factor VIIC, fibrinogen, and cholesterol were between 6% and 10% higher in postmenopausal women than in premenopausal women of the same age. When allowances were made for associations between these variables, the difference between the two groups in cholesterol was no longer evident. By analogy with NPHS data on men, the differences in factor VIIC, fibrinogen, and cholesterol would increase the risk of fatal IHD in postmenopausal women by about 40% compared with the risk in premenopausal women of the same age.
Authors:
T W Meade; A P Haines; J D Imeson; Y Stirling; S G Thompson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  22-4     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Cholesterol / blood
Contraceptives, Oral / administration & dosage
Coronary Disease / blood*
Factor VII / analysis
Female
Fibrinogen / analysis
Hemostasis*
Humans
Menopause*
Middle Aged
Risk
Chemical
Reg. No./Substance:
0/Contraceptives, Oral; 57-88-5/Cholesterol; 9001-25-6/Factor VII; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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