Document Detail


Menisporopsin B, a new polyester from the seed fungus Menisporopsis theobromae BCC 4162.
MedLine Citation:
PMID:  18276999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new linear polyester, menisporopsin B, along with the known macrocyclic polyester, menisporopsin A, was isolated from the seed fungus Menisporopsis theobromae BCC 4162. The structure of menisposopsin B was addressed primarily by spectroscopic analyses, and the stereochemistry was established by chemical correlation. Menisporopsin B exhibited antimalarial activity with an IC(50) value of 1.0 microg/ml.
Authors:
Vasimon Ruanglek; Supichar Chokpaiboon; Nakul Rattanaphan; Siribhorn Madla; Patchanee Auncharoen; Taridaporn Bunyapaiboonsri; Masahiko Isaka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  60     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-02-15     Completed Date:  2008-05-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  748-51     Citation Subset:  IM    
Affiliation:
National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong Luang, Pathumthani, Thailand.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antimalarials / chemistry,  isolation & purification*,  pharmacology*
Fungi / metabolism*
Inhibitory Concentration 50
Macrolides / chemistry,  isolation & purification*,  pharmacology*
Molecular Conformation
Molecular Structure
Plasmodium falciparum / drug effects
Polyesters / chemistry,  isolation & purification*,  pharmacology*
Spectrum Analysis
Chemical
Reg. No./Substance:
0/Antimalarials; 0/Macrolides; 0/Polyesters; 0/menisporopsin A; 0/menisporopsin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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