Document Detail

Meniscal calcification, pathogenesis and implications.
MedLine Citation:
PMID:  22227878     Owner:  NLM     Status:  Publisher    
PURPOSE OF REVIEW: The purpose of this review is to discuss recent advances in the understanding of the nature of meniscal calcification and its relationships with meniscal degeneration and cartilage lesions in osteoarthritis. RECENT FINDINGS: Calcium crystals are universally present in hyaline articular cartilage, as well as the meniscus of the knee of end-stage osteoarthritis patients. Osteoarthritis meniscal cells display a distinct gene-expression profile different from normal meniscal cells, have elevated expression of ankylosis progressive analog (ANKH) and ectonucleotide pyrophosphatase/phosphodiesterase1 (ENPP1) and produce more calcium minerals than normal meniscal cells in vitro. Meniscal calcification is positively associated with meniscal degeneration, which is an early event in the development of osteoarthritis and correlates with cartilage lesions and clinical osteoarthritis scores. Phosphocitrate is a potent calcification inhibitor of osteoarthritis meniscal cell-mediated calcium deposition. Its effect on preventing meniscal degeneration and the molecular mechanisms underlying its disease-modifying activity in osteoarthritis remains elusive. SUMMARY: Recent findings support a pathogenic role of meniscal calcification in osteoarthritis. Meniscal calcification, similar to meniscal degeneration, is a predisposing factor for cartilage lesions. Meniscal calcification is a new target for the development of therapeutic disease-modifying drugs for osteoarthritis.
Yubo Sun; David R Mauerhan
Related Documents :
8515758 - Purification of human muscle satellite cells by flow cytometry.
2834608 - Improvement of a procedure for preparing single smooth muscle cells from guinea pig ten...
20644508 - Isolation of human umbilical arterial smooth muscle cells (huasmc).
10669638 - Fluid flow releases fibroblast growth factor-2 from human aortic smooth muscle cells.
18253178 - Liquid-crystal cell with a wide viewing angle and a high cell contrast.
22909278 - A long-awaited discovery: hypoxia prevents mouse cells from undergoing spontaneous p53-...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-5
Journal Detail:
Title:  Current opinion in rheumatology     Volume:  -     ISSN:  1531-6963     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000851     Medline TA:  Curr Opin Rheumatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Orthopedic Surgery, Carolinas Medical Center, Charlotte, North Carolina, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Association between cumulative fiber exposure and respiratory outcomes among libby vermiculite worke...
Next Document:  Disability due to gouty arthritis.