Document Detail

Meningovascular syphilis with a gumma of the midbrain.
MedLine Citation:
PMID:  1836794     Owner:  NLM     Status:  MEDLINE    
We report a patient with meningovascular syphilis who had a dorsal midbrain syndrome, cognitive dysfunction, and a left peripheral seventh nerve palsy. Magnetic resonance imaging (MRI) disclosed a large lesion of the midbrain and thalamus with intense enhancement of the interpeduncular cistern, both of which resolved after treatment with intravenous penicillin. The clinical features, radiographic appearance, and response to therapy suggest that this lesion was a focal syphilitic inflammatory process, or gumma. We conclude that MRI with intravenous contrast may reveal the full spectrum of pathologic involvement in neurosyphilis and, in certain situations, may obviate the need for biopsy of an associated mass lesion.
D G Standaert; S L Galetta; S W Atlas
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical neuro-ophthalmology     Volume:  11     ISSN:  0272-846X     ISO Abbreviation:  J Clin Neuroophthalmol     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1992-02-06     Completed Date:  1992-02-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8109051     Medline TA:  J Clin Neuroophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  139-43     Citation Subset:  IM    
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia.
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MeSH Terms
Encephalitis / complications,  pathology*
Facial Paralysis / etiology
Follow-Up Studies
Magnetic Resonance Imaging
Mesencephalon* / pathology
Neurosyphilis / complications,  pathology*
Penicillins / therapeutic use
Reg. No./Substance:

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