| Meningoencephalitis from Borrelia miyamotoi in an immunocompromised patient. | |
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MedLine Citation:
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PMID: 23323900 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ixodes ticks serve as vectors for Borrelia burgdorferi, the agent of Lyme disease. Globally, these ticks often concurrently harbor B. miyamotoi, a spirochete that is classified within the relapsing-fever group of spirochetes. Although humans presumably are exposed to B. miyamotoi, there are limited data suggesting disease attributable to it. We report a case of progressive mental deterioration in an older, immunocompromised patient, and even though Koch's postulates were not met, we posit B. miyamotoi as the cause, owing to its direct detection in cerebrospinal fluid (CSF) with the use of microscopy and a polymerase-chain-reaction (PCR) assay. It is likely that B. miyamotoi is an underrecognized cause of disease, especially in sites where Lyme disease is endemic. |
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Authors:
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Joseph L Gugliotta; Heidi K Goethert; Victor P Berardi; Sam R Telford |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The New England journal of medicine Volume: 368 ISSN: 1533-4406 ISO Abbreviation: N. Engl. J. Med. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-17 Completed Date: 2013-01-23 Revised Date: 2013-02-25 |
Medline Journal Info:
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Nlm Unique ID: 0255562 Medline TA: N Engl J Med Country: United States |
Other Details:
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Languages: eng Pagination: 240-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, Division of Infectious Disease, Hunterdon Medical Center, Flemington, New Jersey, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged, 80 and over Borrelia / cytology, genetics, isolation & purification* Borrelia Infections / complications, diagnosis*, immunology Cerebrospinal Fluid / microbiology Cognition Disorders / etiology Female Humans Immunocompromised Host* Meningoencephalitis / diagnosis*, microbiology Phylogeny Polymerase Chain Reaction |
| Grant Support | |
ID/Acronym/Agency:
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R21 AI 082436/AI/NIAID NIH HHS; R21 AI082436/AI/NIAID NIH HHS; R41 AI 078631/AI/NIAID NIH HHS; R41 AI078631/AI/NIAID NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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