Document Detail


Meningoencephalitis from Borrelia miyamotoi in an immunocompromised patient.
MedLine Citation:
PMID:  23323900     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ixodes ticks serve as vectors for Borrelia burgdorferi, the agent of Lyme disease. Globally, these ticks often concurrently harbor B. miyamotoi, a spirochete that is classified within the relapsing-fever group of spirochetes. Although humans presumably are exposed to B. miyamotoi, there are limited data suggesting disease attributable to it. We report a case of progressive mental deterioration in an older, immunocompromised patient, and even though Koch's postulates were not met, we posit B. miyamotoi as the cause, owing to its direct detection in cerebrospinal fluid (CSF) with the use of microscopy and a polymerase-chain-reaction (PCR) assay. It is likely that B. miyamotoi is an underrecognized cause of disease, especially in sites where Lyme disease is endemic.
Authors:
Joseph L Gugliotta; Heidi K Goethert; Victor P Berardi; Sam R Telford
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The New England journal of medicine     Volume:  368     ISSN:  1533-4406     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-17     Completed Date:  2013-01-23     Revised Date:  2013-02-25    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  240-5     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, Division of Infectious Disease, Hunterdon Medical Center, Flemington, New Jersey, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged, 80 and over
Borrelia / cytology,  genetics,  isolation & purification*
Borrelia Infections / complications,  diagnosis*,  immunology
Cerebrospinal Fluid / microbiology
Cognition Disorders / etiology
Female
Humans
Immunocompromised Host*
Meningoencephalitis / diagnosis*,  microbiology
Phylogeny
Polymerase Chain Reaction
Grant Support
ID/Acronym/Agency:
R21 AI 082436/AI/NIAID NIH HHS; R21 AI082436/AI/NIAID NIH HHS; R41 AI 078631/AI/NIAID NIH HHS; R41 AI078631/AI/NIAID NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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