Document Detail


Meningococcal antibody titres in infants of women immunised with meningococcal polysaccharide vaccine during pregnancy.
MedLine Citation:
PMID:  8653435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Seventy five Gambian women were immunised with a single dose of a group A+group C meningococcal polysaccharide vaccine during the last trimester of pregnancy. IgG antibody titres were measured in mothers and in their infants by an enzyme-linked immunosorbent assay (ELISA). All women had a good response to vaccination and maternal antibodies were high at the time of delivery (23.2 micrograms/ml for group A antibodies and 14.3 micrograms/ml for group C antibodies). However, only a proportion of this antibody crossed the placenta; cord blood:maternal antibody ratios were 30% for group A antibody and 44% for group C antibody, respectively. Considerable variability in cord blood:maternal blood ratios was seen between individuals. This could not be related to age, parity, or ethnic group. Mean group A and group C cord blood:maternal blood ratios were lower in women with serological evidence of syphilis than in seronegative women, and diminished transfer of group A antibody was noted in women with active malarial infection of the placenta. Antibody titres declined rapidly in infants and by the age of 3-4 months these had reached control values. Maternal immunisation may give infants some protection against group A and group C meningococcal disease but only during the first few months of life.
Authors:
T J O'Dempsey; T McArdle; S J Ceesay; O Secka; E Demba; W A Banya; N Francis; B M Greenwood
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  74     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-07-31     Completed Date:  1996-07-31     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  F43-6     Citation Subset:  AIM; IM    
Affiliation:
Medical Research Council Laboratories, Banjul, Gambia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Bacterial / blood*
Bacterial Vaccines / administration & dosage,  immunology*
Female
Fetal Blood / immunology
Gambia
Humans
Immunization*
Infant
Infant, Newborn
Maternal-Fetal Exchange*
Meningococcal Vaccines
Neisseria meningitidis / immunology*
Pregnancy
Pregnancy Trimester, Third
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Bacterial Vaccines; 0/Meningococcal Vaccines
Comments/Corrections

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