| Meningococcal disease and future drug targets. | |
| | |
MedLine Citation:
|
PMID: 20874698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Neisseria meningitidis (N. meningitidis) causes sepsis, epidemic meningitis, and sometimes also meningoencephalitis. Despite early antibiotic treatment, mortality and morbidity remain significant. We present recent studies on meningococcal disease with focus on the pathophysiology caused by bacterial virulence factors and the host immune responses. The bacterial outer membrane lipopolysaccharide and non-lipopolysaccharide components are related to meningococcal adhesion and invasion, while the host immune reactions propagate inflammation and neurodegeneration. Hence, bacterium-host interactions are key determinants of the clinical course and risk of fatal outcome. Accordingly, successful treatment of severe meningococcal disease requires not only antibiotics but also adjuvants targeting the released endotoxins and the host immune/inflammatory responses. This review highlights the most recent data and current knowledge on molecular mechanisms of meningococcal disease and explains how host immune responses ultimately may aggravate neuropathology and the clinical prognosis. Within this context, particular importance is paid to the endotoxic components that provide potential drug targets for novel neuroprotective adjuvants, which are needed in order to improve the clinical management of meningoencephalitis and patient prognosis. |
| | |
Authors:
|
L K Gammelgaard; H Colding; S H Hartzen; M Penkowa |
Related Documents
:
|
20974828 - Lipoproteins of bacterial pathogens. 11402018 - Francisella tularensis induces cytopathogenicity and apoptosis in murine macrophages vi... 17176758 - Inhibition of mammalian cathepsins by plesiomonas shigelloides. 19203648 - Diversity in bacterial chemotactic responses and niche adaptation. 2070198 - Characterisation of inflammatory cells associated with "idiopathic retroperitoneal fibr... 1372488 - Biological activities and potential therapeutic uses of steel factor. a new growth fact... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: CNS & neurological disorders drug targets Volume: 10 ISSN: 1996-3181 ISO Abbreviation: CNS Neurol Disord Drug Targets Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-25 Completed Date: 2011-07-29 Revised Date: 2012-04-09 |
Medline Journal Info:
|
Nlm Unique ID: 101269155 Medline TA: CNS Neurol Disord Drug Targets Country: United Arab Emirates |
Other Details:
|
Languages: eng Pagination: 140-5 Citation Subset: IM |
Affiliation:
|
Section of Neuroprotection, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, 18.1.44, DK-2200 Copenhagen, Denmark. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anti-Bacterial Agents
/
therapeutic use* Host-Pathogen Interactions Humans Meningitis, Meningococcal / drug therapy, immunology, microbiology, pathology Meningococcal Infections* / drug therapy, immunology, microbiology, pathology Meningoencephalitis / drug therapy, immunology, microbiology, pathology Molecular Targeted Therapy Neisseria meningitidis* / drug effects, immunology, pathogenicity Virulence Factors / toxicity |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Bacterial Agents; 0/Virulence Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Non-cholinergic pharmacotherapy approaches to Alzheimer's disease: the use of non-steroidal anti-inf...
Next Document: Are anti-angiogenic drugs useful in neurodegenerative disorders?