Document Detail

Meningitis in preterm neonates: importance of cerebrospinal fluid parameters.
MedLine Citation:
PMID:  18726835     Owner:  NLM     Status:  MEDLINE    
Cerebrospinal fluid parameters are of great importance in diagnosing meningitis, but normal values for preterm neonates are based on small, single-center studies. We sought to determine current values for preterm neonate cerebrospinal fluid parameters and assess the association of cerebrospinal fluid parameters with culture proven meningitis. We performed a cohort study of the first lumbar puncture from 4632 neonates < 34 weeks' gestation performed in the years 1997 to 2004 at 150 neonatal intensive care units managed by the Pediatrix Medical Group. We identified 95 cases of meningitis from the 4632 lumbar punctures. The area under the receiver operating characteristic curves for white blood cell count, glucose, and protein were 0.80, 0.63, and 0.72, respectively, for prediction of culture-proven meningitis. Cerebrospinal fluid parameters used to diagnose meningitis in the absence of dependable cerebrospinal fluid cultures are unreliable. Caution should be employed when interpreting cerebrospinal fluid parameters in the premature neonate.
P Brian Smith; Harmony P Garges; C Michael Cotton; Thomas J Walsh; Reese H Clark; Daniel K Benjamin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-08-22
Journal Detail:
Title:  American journal of perinatology     Volume:  25     ISSN:  1098-8785     ISO Abbreviation:  Am J Perinatol     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-09-29     Completed Date:  2009-01-23     Revised Date:  2013-12-18    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  421-6     Citation Subset:  IM    
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MeSH Terms
Cerebrospinal Fluid Proteins
Cohort Studies
Gestational Age
Glucose / cerebrospinal fluid
Infant, Newborn
Infant, Premature, Diseases / cerebrospinal fluid*,  diagnosis,  epidemiology*
Intensive Care Units, Neonatal / statistics & numerical data
Leukocyte Count
Meningitis, Bacterial / cerebrospinal fluid*,  diagnosis,  epidemiology*
Predictive Value of Tests
ROC Curve
Spinal Puncture
Grant Support
HD044799-01/HD/NICHD NIH HHS; K23 HD044799/HD/NICHD NIH HHS; T32 HD-043728-01A2/HD/NICHD NIH HHS; T32 HD043728/HD/NICHD NIH HHS; T32 HD043728-01A2/HD/NICHD NIH HHS
Reg. No./Substance:
0/Cerebrospinal Fluid Proteins; IY9XDZ35W2/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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