Document Detail

Meningioma mouse models.
MedLine Citation:
PMID:  20734219     Owner:  NLM     Status:  MEDLINE    
Meningiomas, although mostly benign, may sometimes present aggressive features and raise issues concerning alternative treatment options besides surgery. In order to gain new insights in meningioma biology and develop alternative treatments, several meningioma mouse models have been engineered during the past two decades. As rodents very rarely develop spontaneous meningiomas, animal models have been first developed by implanting human meningioma cells derived from a primary tumor and meningioma cell lines subcutaneously into athymic mice. Induction of de novo meningiomas in rodents with mutagens, such as nitrosourea, has also been reported. Advances in our understanding of molecular genetics of meningioma have pinpointed the central role of NF2 tumor suppressor gene in the pathogenesis of those tumors. These discoveries have led to the creation of a genetically engineered model utilizing conditional mutagenesis to specifically inactivate the mouse Nf2 gene in arachnoidal cells, resulting in the formation of intracranial meningothelial hyperplasia and meningiomas and thus reproducing the main mechanism of human meningeal tumorigenesis. This powerful new technology significantly improves on prior models and may open avenues of investigation never before possible in meningioma research. We present here a review of current meningioma mouse models used in translational therapeutics with associated imaging and pre-clinical studies.
Michel Kalamarides; Matthieu Peyre; Marco Giovannini
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-08-24
Journal Detail:
Title:  Journal of neuro-oncology     Volume:  99     ISSN:  1573-7373     ISO Abbreviation:  J. Neurooncol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2011-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309335     Medline TA:  J Neurooncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  325-31     Citation Subset:  IM    
Department of Neurosurgery, APHP, Hopital Beaujon, Service de Neurochirurgie, 100 bvd du general Leclerc, Clichy, France.
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MeSH Terms
Disease Models, Animal*
Meningeal Neoplasms / etiology,  pathology*
Meningioma / etiology,  pathology*

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