Document Detail

Mending a growth-restricted fetal heart: should we use glucocorticoids?
MedLine Citation:
PMID:  22764774     Owner:  NLM     Status:  Publisher    
Clinical and experimental studies suggest that the growth-restricted fetus at increased risk of impaired cardiovascular function that likely contributes to both increased mortality rate and in survivors, to cardiovascular dysfunction apparent in childhood and later life. Fetal growth restriction is also associated with a high risk of preterm birth. Accordingly, the growth-restricted fetus is more likely than average to receive antenatal glucocorticoids to accelerate lung maturation in preparation for birth. However, glucocorticoids are powerful regulators of vascular tone and antenatal glucocorticoid administration to the intrauterine growth restriction (IUGR) fetus results in systemic cardiovascular changes that are not observed in the healthy normal grown fetus. These responses to glucocorticoids may disturb the IUGR fetus' ability to appropriately compensate to placental insufficiency. Indeed is it possible that in the setting of severe IUGR exogenous glucocorticoids are detrimental rather than beneficial to the fetus?
Ryan J Hodges; Euan M Wallace
Related Documents :
20498944 - Anesthetic management in intrauterine surgery to evaluate an experimental model of myel...
8692494 - Pregnancy-related mortality in the united states, 1987-1990.
1446274 - Stillbirths, mummies, abortions, and early embryonic death.
1592004 - Risk factors associated with antepartum fetal death.
9974454 - Prenatal and perinatal risk factors for schizophrenia, affective psychosis, and reactiv...
20487114 - Fetal atrioventricular block and postpartum augmentative qt prolongation in a patient w...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-6
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Maternal Fetal Medicine, Monash Medical Centre , Southern Health, Victoria , Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Subcutaneous diffuse large B-cell lymphoma with intraocular involvement.
Next Document:  A nonhuman primate model of lung regeneration: detergent-mediated decellularization and initial in v...