| Mendelian randomization: use of genetics to enable causal inference in observational studies. | |
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MedLine Citation:
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PMID: 20190244 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of aetiologic studies in epidemiology is to investigate whether factors are causally related to diseases and therefore become a potential target for therapeutic interventions. Mendelian randomization enables estimation of causal relationships in observational studies using genetic variants as instrumental variables. An instrumental variable is a variable that can be considered to mimic the coin toss in a randomized study. Given the random assignment of alleles in gamete formation, the use of genetic variants is an alternative method to control for confounding. This educational article describes the approach of Mendelian randomization, its underlying rationale and its necessary assumptions. |
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Authors:
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Marion Verduijn; Bob Siegerink; Kitty J Jager; Carmine Zoccali; Friedo W Dekker |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-26 |
Journal Detail:
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Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 25 ISSN: 1460-2385 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-20 Completed Date: 2010-08-09 Revised Date: 2010-10-04 |
Medline Journal Info:
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Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: England |
Other Details:
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Languages: eng Pagination: 1394-8 Citation Subset: IM |
Affiliation:
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Department of Clinical Epidemiology, Leiden University Medical Center, P.O. Box 9600 2300 RC Leiden, The Netherlands. m.verduijn@lumc.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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C-Reactive Protein
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analysis Cholesterol / blood Genetic Variation* Humans Mendelian Randomization Analysis* Myocardial Ischemia / etiology Neoplasms / etiology Risk Factors |
| Chemical | |
Reg. No./Substance:
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57-88-5/Cholesterol; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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