Document Detail

Memory retrieval and its lasting consequences.
MedLine Citation:
PMID:  12754168     Owner:  NLM     Status:  Publisher    
Many, if not all psychiatric diseases are accompanied by memory disturbances, in particular, the dementias, schizophrenia, and, to an extent, mood disorders. Anxiety and stress, on the other hand, cause important alterations of memory, particularly its retrieval. Here we discuss several new findings on the basic mechanisms of consolidation, retrieval and extinction of a prototype form of episodic memory in the rat: conditioned fear. The findings point the way for investigations on the pathology of these aspects of memory in health and disease. Emphasis is placed on the parallel processing of retrieval in several cortical areas, on the links between retrieval and the onset of extinction, on the fact that extinction involves new learning requiring gene expression, and on the differences between the retrieval of recent or remote long-term memories.
Iván Izquierdo; Mónica R.M. Vianna; Luciana A. Izquierdo; Daniela M. Barros; Germán Szapiro; Adriana S. Coitinho; Lionel Muller; Martín Cammarota; Lia R.M. Bevilaqua; Jorge H. Medina
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Publication Detail:
Journal Detail:
Title:  Neurotoxicity research     Volume:  4     ISSN:  1476-3524     ISO Abbreviation:  Neurotox Res     Publication Date:    2002 Aug-Sep
Date Detail:
Created Date:  2003-May-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100929017     Medline TA:  Neurotox Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  573-593     Citation Subset:  -    
Departamento de Bioquímica, Centro de Memoria, Instituto de Ciencias Básicas da Saúde, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brasil.
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