Document Detail


Memory performance, brain excitatory amino acid and acetylcholinesterase activity of chronically aluminum exposed mice in response to soy isoflavones treatment.
MedLine Citation:
PMID:  20878693     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Memory performance, brain excitatory amino acid and acetylcholinesterase activity of chronically aluminum (Al) exposed mice in response to soy isoflavones (SI) treatment was investigated in the study. Forty eight mice were allotted randomly into a control group, an Al exposed group (100 mg/kg Al) and an Al exposed group treated with SI (100 mg/kg Al + 60 mg/kg SI) for 60 days. Chronic Al exposure significantly impaired long memory performance in mice as assessed using a passive avoidance task test (χ(2) analysis, p < 0.05). Interestingly, SI treatment markedly improved the memory performance score in the Al exposed mice. This improvement was associated with a total reversal of Al-induced increases in acetylcholinesterase activity in the cerebral cortex and hippocampus of mice. The Al exposure also led to significant decreases in brain levels of aspartic and glutamic acids, two excitatory amino acid neurotransmitters; whereas SI treatment partially reversed the decreased aspartic and glutamic acid contents in the hippocampus. The results suggest that SI can improve long memory performance in the Al exposed mice, possibly by modulating the metabolism of brain acetylcholine and amino acid neurotransmitters.
Authors:
Yan-qiang Liu; Tian-rong Xin; Jing-jing Liang; Wei-ming Wang; Yuan-yuan Zhang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  24     ISSN:  1099-1573     ISO Abbreviation:  Phytother Res     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-29     Completed Date:  2011-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1451-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 John Wiley & Sons, Ltd.
Affiliation:
College of Life Sciences, Nankai University, Tianjin 300071, China. liuyanq@nankai.edu.cn
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MeSH Terms
Descriptor/Qualifier:
Acetylcholinesterase / analysis*
Aluminum / adverse effects*
Animals
Avoidance Learning / drug effects
Brain / metabolism*
Excitatory Amino Acids / analysis*
Isoflavones / pharmacology*
Male
Memory / drug effects*
Mice
Soybeans / chemistry
Chemical
Reg. No./Substance:
0/Excitatory Amino Acids; 0/Isoflavones; 7429-90-5/Aluminum; EC 3.1.1.7/Acetylcholinesterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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