| Memory performance, brain excitatory amino acid and acetylcholinesterase activity of chronically aluminum exposed mice in response to soy isoflavones treatment. | |
| | |
MedLine Citation:
|
PMID: 20878693 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Memory performance, brain excitatory amino acid and acetylcholinesterase activity of chronically aluminum (Al) exposed mice in response to soy isoflavones (SI) treatment was investigated in the study. Forty eight mice were allotted randomly into a control group, an Al exposed group (100 mg/kg Al) and an Al exposed group treated with SI (100 mg/kg Al + 60 mg/kg SI) for 60 days. Chronic Al exposure significantly impaired long memory performance in mice as assessed using a passive avoidance task test (χ(2) analysis, p < 0.05). Interestingly, SI treatment markedly improved the memory performance score in the Al exposed mice. This improvement was associated with a total reversal of Al-induced increases in acetylcholinesterase activity in the cerebral cortex and hippocampus of mice. The Al exposure also led to significant decreases in brain levels of aspartic and glutamic acids, two excitatory amino acid neurotransmitters; whereas SI treatment partially reversed the decreased aspartic and glutamic acid contents in the hippocampus. The results suggest that SI can improve long memory performance in the Al exposed mice, possibly by modulating the metabolism of brain acetylcholine and amino acid neurotransmitters. |
| | |
Authors:
|
Yan-qiang Liu; Tian-rong Xin; Jing-jing Liang; Wei-ming Wang; Yuan-yuan Zhang |
Related Documents
:
|
2871693 - Effect on brain monoamines in the rat of substituted and protected analogues of the oxy... 1980143 - Ante mortem cerebral amino acid concentrations indicate selective degeneration of gluta... 3429333 - Uptake and release of ascorbic acid by rat leydig cells in vitro. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Phytotherapy research : PTR Volume: 24 ISSN: 1099-1573 ISO Abbreviation: Phytother Res Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-29 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
|
Languages: eng Pagination: 1451-6 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 John Wiley & Sons, Ltd. |
Affiliation:
|
College of Life Sciences, Nankai University, Tianjin 300071, China. liuyanq@nankai.edu.cn |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetylcholinesterase
/
analysis* Aluminum / adverse effects* Animals Avoidance Learning / drug effects Brain / metabolism* Excitatory Amino Acids / analysis* Isoflavones / pharmacology* Male Memory / drug effects* Mice Soybeans / chemistry |
| Chemical | |
Reg. No./Substance:
|
0/Excitatory Amino Acids; 0/Isoflavones; 7429-90-5/Aluminum; EC 3.1.1.7/Acetylcholinesterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A new antitumor arabinopyranoside from Laurencia majuscula induces G2/M cell cycle arrest.
Next Document: Evaluation of in vivo antihypertensive and in vitro vasodepressor activities of the leaf extract of ...